Yury V Gavrilov1,2,3, Brian A Ellison1, Mihoko Yamamoto1, Hasini Reddy4, Johannes Haybaeck5, Emmanuel Mignot6, Christian R Baumann1,2, Thomas E Scammell1, Philipp O Valko1,2. 1. Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA. 2. Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland. 3. Department of General Pathology and Pathological Physiology, Institute of Experimental Medicine, St. Petersburg, Russia. 4. Department of Neuropathology, Beth Israel Deaconess Medical Center, Boston, MA. 5. Department of Neuropathology, Institute of Pathology, Medical University of Graz, Austria. 6. Department of Psychiatry, Stanford University Center for Narcolepsy, Palo Alto, CA.
Abstract
STUDY OBJECTIVES: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. METHODS: Postmortem examination of five narcolepsy and eight control brains. RESULTS: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). CONCLUSIONS: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.
STUDY OBJECTIVES: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. METHODS: Postmortem examination of five narcolepsy and eight control brains. RESULTS: VLPO galanin neuron count did not differ between narcolepsypatients (11,151 ± 3,656) and controls (13,526 ± 9,544). CONCLUSIONS: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.
Authors: Rhannan H Williams; Melissa J S Chee; Daniel Kroeger; Loris L Ferrari; Eleftheria Maratos-Flier; Thomas E Scammell; Elda Arrigoni Journal: J Neurosci Date: 2014-04-23 Impact factor: 6.167
Authors: Andrew S P Lim; Brian A Ellison; Joshua L Wang; Lei Yu; Julie A Schneider; Aron S Buchman; David A Bennett; Clifford B Saper Journal: Brain Date: 2014-08-20 Impact factor: 13.501
Authors: Philipp O Valko; Yury V Gavrilov; Mihoko Yamamoto; Hasini Reddy; Johannes Haybaeck; Emmanuel Mignot; Christian R Baumann; Thomas E Scammell Journal: Ann Neurol Date: 2013-12 Impact factor: 10.422
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