Literature DB >> 2694954

Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391.

E Inoue1, S Mitsuhashi.   

Abstract

The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.

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Year:  1989        PMID： 2694954      PMCID： PMC172843          DOI： 10.1128/AAC.33.12.2157

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Purification and properties of chromosomally mediated beta-lactamase from Citrobacter freundii GN7391.

Authors:  M Tajima; Y Takenouchi; S Sugawara; M Inoue; S Mitsuhashi
Journal:  J Gen Microbiol       Date:  1980-12

2.  Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae.

Authors:  S Minami; A Yotsuji; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-09       Impact factor: 5.191

3.  Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.

Authors:  M Hiraoka; M Inoue; S Mitsuhashi
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

4.  In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.

Authors:  N Watanabe; K Katsu; M Moriyama; K Kitoh
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

5.  Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime.

Authors:  M Hiraoka; S Masuyoshi; S Mitsuhashi; K Tomatsu; M Inoue
Journal:  J Antibiot (Tokyo)       Date:  1988-01       Impact factor: 2.649

6.  Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams.

Authors:  H Vu; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

7.  In vitro activity of E-1040, a novel cephalosporin with potent activity against Pseudomonas aeruginosa.

Authors:  H C Neu; N X Chin; A Novelli
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

8.  Effects of beta-lactamases and omp mutation on susceptibility to beta-lactam antibiotics in Escherichia coli.

Authors:  M Hiraoka; R Okamoto; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191

9.  Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391.

Authors:  S Satake; M Hiraoka; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191
  9 in total
  2 in total

1.  In vitro and in vivo activities of DQ-2556 and its mode of action.

Authors:  M Tanaka; M Otsuki; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

2.  In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains.

Authors:  M Watanabe; E Inoue; K Katsu; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191
  2 in total

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