Anne Dathan-Stumpf1, Mandy Vogel2, Andreas Hiemisch3, Joachim Thiery4, Ralph Burkhardt5, Jürgen Kratzsch6, Wieland Kiess7. 1. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Hospital for Children and Adolescents, University of Leipzig, 04103 Leipzig, Germany; Centre of Paediatric Research (CPL), Leipzig University, 04103 Leipzig, Germany. Electronic address: anne_dathan@web.de. 2. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Centre of Paediatric Research (CPL), Leipzig University, 04103 Leipzig, Germany. Electronic address: mandy.vogel@life.uni-leipzig.de. 3. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Hospital for Children and Adolescents, University of Leipzig, 04103 Leipzig, Germany; Centre of Paediatric Research (CPL), Leipzig University, 04103 Leipzig, Germany. Electronic address: andreas.hiemisch@medizin.uni-leipzig.de. 4. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, 04103 Leipzig, Germany. Electronic address: mb-sek-ilm@medizin.uni-leipzig.de. 5. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, 04103 Leipzig, Germany. Electronic address: ralph.burkhardt@medizin.uni-leipzig.de. 6. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, 04103 Leipzig, Germany. Electronic address: juergen.kratzsch@medizin.uni-leipzig.de. 7. Leipzig University, LIFE-Child-Leipzig Research Center for Civilization Diseases, 04103 Leipzig, Germany; Hospital for Children and Adolescents, University of Leipzig, 04103 Leipzig, Germany; Centre of Paediatric Research (CPL), Leipzig University, 04103 Leipzig, Germany. Electronic address: wieland.kiess@medizin.uni-leipzig.de.
Abstract
BACKGROUND: Serum lipid concentrations are thought to be risk factors for the development of cardiovascular disease. The present study aims to investigate the prevalence of dyslipidemia and provide sex- and age-related reference values for triglycerides, total cholesterol, LDL and HDL cholesterol as well as apolipoproteins A1 and B by using modern analytical approaches. MATERIALS AND METHODS: Venous blood and anthropometric data were collected from 2571 subjects of the LIFE Child study, aged between 0.5 and 16years. Age- and gender-related reference intervals (3rd and 97th percentiles) were established by using Cole's LMS method. RESULTS: Serum concentrations of TC, LDL-C, TG and ApoB were higher in girls than in boys. In girls TC reached peak levels two years earlier than in boys. Triglyceride levels initially declined until the school age. Until early adolescence there was a steady increase. The LDL-C concentrations in girls and boys followed similar patterns to that of TC. Up to the age of 8years, a continuous increase in HDL levels for both sexes was found. Due to the strong correlation between HDL-C and ApoA1 (r=0.87) or rather between LDL-C and ApoB (r=0.93), the respective percentiles showed very similar patterns. Dyslipidemia prevalence were as follows: increased TC 7.8%, increased LDL 6.1%, increased TG 0-9years 22.1%, increased TG 10-16years 11.7%, and decreased HDL 8.0%. CONCLUSION: Age- and sex-related trends for all parameters are similar to those of the German KIGGS study. With the exception of HDL cholesterol, the prevalence of dyslipidemias in the German LIFE Child cohort are similar to the US-American prevalence.
BACKGROUND: Serum lipid concentrations are thought to be risk factors for the development of cardiovascular disease. The present study aims to investigate the prevalence of dyslipidemia and provide sex- and age-related reference values for triglycerides, total cholesterol, LDL and HDL cholesterol as well as apolipoproteins A1 and B by using modern analytical approaches. MATERIALS AND METHODS: Venous blood and anthropometric data were collected from 2571 subjects of the LIFE Child study, aged between 0.5 and 16years. Age- and gender-related reference intervals (3rd and 97th percentiles) were established by using Cole's LMS method. RESULTS: Serum concentrations of TC, LDL-C, TG and ApoB were higher in girls than in boys. In girlsTC reached peak levels two years earlier than in boys. Triglyceride levels initially declined until the school age. Until early adolescence there was a steady increase. The LDL-C concentrations in girls and boys followed similar patterns to that of TC. Up to the age of 8years, a continuous increase in HDL levels for both sexes was found. Due to the strong correlation between HDL-C and ApoA1 (r=0.87) or rather between LDL-C and ApoB (r=0.93), the respective percentiles showed very similar patterns. Dyslipidemia prevalence were as follows: increased TC 7.8%, increased LDL 6.1%, increased TG 0-9years 22.1%, increased TG 10-16years 11.7%, and decreased HDL 8.0%. CONCLUSION: Age- and sex-related trends for all parameters are similar to those of the German KIGGS study. With the exception of HDL cholesterol, the prevalence of dyslipidemias in the German LIFE Child cohort are similar to the US-American prevalence.
Authors: Sina K Stumpf; Stefan A Berghoff; Andrea Trevisiol; Lena Spieth; Tim Düking; Lennart V Schneider; Lennart Schlaphoff; Steffi Dreha-Kulaczewski; Annette Bley; Dinah Burfeind; Kathrin Kusch; Miso Mitkovski; Torben Ruhwedel; Philipp Guder; Heiko Röhse; Jonas Denecke; Jutta Gärtner; Wiebke Möbius; Klaus-Armin Nave; Gesine Saher Journal: Acta Neuropathol Date: 2019-03-27 Impact factor: 17.088
Authors: Marc-Olivier Deguise; Giovanni Baranello; Chiara Mastella; Ariane Beauvais; Jean Michaud; Alessandro Leone; Ramona De Amicis; Alberto Battezzati; Christopher Dunham; Kathryn Selby; Jodi Warman Chardon; Hugh J McMillan; Yu-Ting Huang; Natalie L Courtney; Alannah J Mole; Sabrina Kubinski; Peter Claus; Lyndsay M Murray; Melissa Bowerman; Thomas H Gillingwater; Simona Bertoli; Simon H Parson; Rashmi Kothary Journal: Ann Clin Transl Neurol Date: 2019-07-26 Impact factor: 4.511
Authors: Lukasz Szczerbinski; Gladys Wojciechowska; Adam Olichwier; Mark A Taylor; Urszula Puchta; Paulina Konopka; Adam Paszko; Anna Citko; Joanna Goscik; Oliver Fiehn; Sili Fan; Anna Wasilewska; Katarzyna Taranta-Janusz; Adam Kretowski Journal: Nutrients Date: 2022-01-04 Impact factor: 5.717