Literature DB >> 26948012

Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.

John W Norbury1, Walter Schimmerling2, Tony C Slaba3, Edouard I Azzam4, Francis F Badavi5, Giorgio Baiocco6, Eric Benton7, Veronica Bindi8, Eleanor A Blakely9, Steve R Blattnig3, David A Boothman10, Thomas B Borak11, Richard A Britten12, Stan Curtis13, Michael Dingfelder14, Marco Durante15, William S Dynan16, Amelia J Eisch10, S Robin Elgart17, Dudley T Goodhead18, Peter M Guida19, Lawrence H Heilbronn20, Christine E Hellweg21, Janice L Huff22, Amy Kronenberg9, Chiara La Tessa19, Derek I Lowenstein19, Jack Miller9, Takashi Morita23, Livio Narici24, Gregory A Nelson25, Ryan B Norman3, Andrea Ottolenghi6, Zarana S Patel17, Guenther Reitz21, Adam Rusek19, Ann-Sofie Schreurs26, Lisa A Scott-Carnell3, Edward Semones17, Jerry W Shay10, Vyacheslav A Shurshakov27, Lembit Sihver28, Lisa C Simonsen3, Michael D Story10, Mitchell S Turker29, Yukio Uchihori30, Jacqueline Williams31, Cary J Zeitlin32.   

Abstract

Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species with a continuous range of energies. Due to recent developments in beam switching technology implemented at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), it is now possible to rapidly switch ion species and energies, allowing for the possibility to more realistically simulate the actual radiation environment found in space. The present paper discusses a variety of issues related to implementation of galactic cosmic ray (GCR) simulation at NSRL, especially for experiments in radiobiology. Advantages and disadvantages of different approaches to developing a GCR simulator are presented. In addition, issues common to both GCR simulation and single beam experiments are compared to issues unique to GCR simulation studies. A set of conclusions is presented as well as a discussion of the technical implementation of GCR simulation. Published by Elsevier Ltd.

Entities:  

Keywords:  Galactic cosmic ray simulation; Space radiation

Mesh:

Year:  2016        PMID: 26948012      PMCID: PMC5771487          DOI: 10.1016/j.lssr.2016.02.001

Source DB:  PubMed          Journal:  Life Sci Space Res (Amst)        ISSN: 2214-5524


  47 in total

1.  Irradiation of multi-cell spheroids with fast neutrons versus X-rays: a qualitative difference in sub-lethal damage repair capacity or kinetics.

Authors:  R E Durand; P L Olive
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2.  Importance of dose-rate and cell proliferation in the evaluation of biological experimental results.

Authors:  S B Curtis
Journal:  Adv Space Res       Date:  1994       Impact factor: 2.152

3.  Planetary exploration. Radiation will make astronauts' trip to Mars even riskier.

Authors:  Richard A Kerr
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4.  Characterisation of a track structure imaging detector.

Authors:  M Casiraghi; V A Bashkirov; R F Hurley; R W Schulte
Journal:  Radiat Prot Dosimetry       Date:  2015-04-15       Impact factor: 0.972

Review 5.  Transcription-replication encounters, consequences and genomic instability.

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Journal:  Nat Struct Mol Biol       Date:  2013-04       Impact factor: 15.369

Review 6.  Comparative cancer potency for silica from extrapolations of human and animal findings.

Authors:  D F Goldsmith; R P Ruble; C O Klein
Journal:  Scand J Work Environ Health       Date:  1995       Impact factor: 5.024

7.  The fragmentation of 670A MeV neon-20 as a function of depth in water. I. Experiment.

Authors:  W Schimmerling; J Miller; M Wong; M Rapkin; J Howard; H G Spieler; B V Jarret
Journal:  Radiat Res       Date:  1989-10       Impact factor: 2.841

8.  Survival of Chinese hamster V79 cells after irradiation with a mixture of neutrons and 60Co gamma rays: experimental and theoretical analysis of mixed irradiation.

Authors:  S Suzuki
Journal:  Radiat Res       Date:  1993-03       Impact factor: 2.841

9.  Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Authors:  Oliver Delgado; Kimberly G Batten; James A Richardson; Xian-Jin Xie; Adi F Gazdar; Aadil A Kaisani; Luc Girard; Carmen Behrens; Milind Suraokar; Gail Fasciani; Woodring E Wright; Michael D Story; Ignacio I Wistuba; John D Minna; Jerry W Shay
Journal:  Clin Cancer Res       Date:  2014-01-31       Impact factor: 12.531

10.  Comparative analysis of cell killing and autosomal mutation in mouse kidney epithelium exposed to 1 GeV protons in vitro or in vivo.

Authors:  Amy Kronenberg; Stacey Gauny; Ely Kwoh; Gianfranco Grossi; Cristian Dan; Dmytro Grygoryev; Michael Lasarev; Mitchell S Turker
Journal:  Radiat Res       Date:  2013-04-05       Impact factor: 2.841

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  26 in total

1.  Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention.

Authors:  Krishna Luitel; Sang Bum Kim; Summer Barron; James A Richardson; Jerry W Shay
Journal:  Life Sci Space Res (Amst)       Date:  2019-08-01

2.  Synergy theory for murine Harderian gland tumours after irradiation by mixtures of high-energy ionized atomic nuclei.

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Journal:  Radiat Environ Biophys       Date:  2019-02-02       Impact factor: 1.925

Review 3.  Behavioral effects of space radiation: A comprehensive review of animal studies.

Authors:  Frederico Kiffer; Marjan Boerma; Antiño Allen
Journal:  Life Sci Space Res (Amst)       Date:  2019-02-19

4.  Whole-Body Exposure to 28Si-Radiation Dose-Dependently Disrupts Dentate Gyrus Neurogenesis and Proliferation in the Short Term and New Neuron Survival and Contextual Fear Conditioning in the Long Term.

Authors:  Cody W Whoolery; Angela K Walker; Devon R Richardson; Melanie J Lucero; Ryan P Reynolds; David H Beddow; K Lyles Clark; Hung-Ying Shih; Junie A LeBlanc; Mara G Cole; Wellington Z Amaral; Shibani Mukherjee; Shichuan Zhang; Francisca Ahn; Sarah E Bulin; Nathan A DeCarolis; Phillip D Rivera; Benjamin P C Chen; Sanghee Yun; Amelia J Eisch
Journal:  Radiat Res       Date:  2017-09-25       Impact factor: 2.841

5.  Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.

Authors:  Tara B Sweet; Sean D Hurley; Michael D Wu; John A Olschowka; Jacqueline P Williams; M Kerry O'Banion
Journal:  Radiat Res       Date:  2016-12-01       Impact factor: 2.841

6.  Neutron Radiobiology and Dosimetry.

Authors:  Daniela L Stricklin; Jama VanHorne-Sealy; Carmen I Rios; Lisa A Scott Carnell; Lanyn P Taliaferro
Journal:  Radiat Res       Date:  2021-05-01       Impact factor: 2.841

7.  Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.

Authors:  Jeremy M Brownstein; Amy J Wisdom; Katherine D Castle; Yvonne M Mowery; Peter Guida; Chang-Lung Lee; Francesco Tommasino; Chiara La Tessa; Emanuele Scifoni; Junheng Gao; Lixia Luo; Lorraine Da Silva Campos; Yan Ma; Nerissa Williams; Sin-Ho Jung; Marco Durante; David G Kirsch
Journal:  Mol Cancer Ther       Date:  2018-02-07       Impact factor: 6.009

8.  Female mice are protected from space radiation-induced maladaptive responses.

Authors:  Karen Krukowski; Katherine Grue; Elma S Frias; John Pietrykowski; Tamako Jones; Gregory Nelson; Susanna Rosi
Journal:  Brain Behav Immun       Date:  2018-08-11       Impact factor: 7.217

9.  Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen.

Authors:  Ratan Sadhukhan; Debajyoti Majumdar; Sarita Garg; Reid D Landes; Victoria McHargue; Snehalata A Pawar; Parimal Chowdhury; Robert J Griffin; Ganesh Narayanasamy; Marjan Boerma; Maxim Dobretsov; Martin Hauer-Jensen; Rupak Pathak
Journal:  Life Sci Space Res (Amst)       Date:  2020-09-29

10.  Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.

Authors:  Sonia M de Toledo; Manuela Buonanno; Andrew L Harris; Edouard I Azzam
Journal:  Int J Radiat Biol       Date:  2017-06-15       Impact factor: 3.352

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