Literature DB >> 26942927

Gene expression profile changes in Eisenia fetida chronically exposed to PFOA.

Srinithi Mayilswami1,2, Kannan Krishnan3,4, Mallavarapu Megharaj2,5, Ravi Naidu2,5.   

Abstract

Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E. fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil.

Entities:  

Keywords:  Differential gene expression; Eisenia fetida; Perfluorooctanoic acid (PFOA); Toxicogenomics; Transcriptome assembly

Mesh：

Substances：

Year:  2016        PMID： 26942927     DOI： 10.1007/s10646-016-1634-x

Source DB:  PubMed          Journal:  Ecotoxicology        ISSN： 0963-9292            Impact factor:   2.823


  48 in total

1.  Identification of the source of PFOS and PFOA contamination at a military air base site.

Authors:  Victor A Arias E; Megharaj Mallavarapu; Ravi Naidu
Journal:  Environ Monit Assess       Date:  2014-11-19       Impact factor: 2.513

2.  Gene expression analysis of CL-20-induced reversible neurotoxicity reveals GABA(A) receptors as potential targets in the earthworm Eisenia fetida.

Authors:  Ping Gong; Xin Guan; Mehdi Pirooznia; Chun Liang; Edward J Perkins
Journal:  Environ Sci Technol       Date:  2012-01-06       Impact factor: 9.028

3.  Quantitative characterization of trace levels of PFOS and PFOA in the Tennessee River.

Authors:  K J Hansen; H O Johnson; J S Eldridge; J L Butenhoff; L A Dick
Journal:  Environ Sci Technol       Date:  2002-04-15       Impact factor: 9.028

4.  Development of a biotic ligand model and a regression model predicting acute copper toxicity to the earthworm Aporrectodea caliginosa.

Authors:  Nathanaël T T M Steenbergen; Federica Iaccino; Maaike de Winkel; Lucas Reijnders; Willie J G M Peijnenburg
Journal:  Environ Sci Technol       Date:  2005-08-01       Impact factor: 9.028

5.  Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA).

Authors:  Keerthi S Guruge; Leo W Y Yeung; Noriko Yamanaka; Shigeru Miyazaki; Paul K S Lam; John P Giesy; Paul D Jones; Nobuyoshi Yamashita
Journal:  Toxicol Sci       Date:  2005-10-12       Impact factor: 4.849

6.  Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity.

Authors:  A Hagenaars; L Vergauwen; D Benoot; K Laukens; D Knapen
Journal:  Chemosphere       Date:  2013-02-18       Impact factor: 7.086

7.  The comet assay as biomarker of heavy metal genotoxicity in earthworms.

Authors:  S A Reinecke; A J Reinecke
Journal:  Arch Environ Contam Toxicol       Date:  2004-02       Impact factor: 2.804

8.  A pilot study on the determination of perfluorooctanesulfonate and other perfluorinated compounds in blood of Canadians.

Authors:  Cariton Kubwabo; Natalia Vais; Frank M Benoit
Journal:  J Environ Monit       Date:  2004-03-22

9.  Cytotoxicity and inhibition of intercellular interaction in N2a neurospheroids by perfluorooctanoic acid and perfluorooctanesulfonic acid.

Authors:  Seong-Kyoon Choi; Jung-Hee Kim; Jin-Kyu Park; Kyeong-Min Lee; Eunjoo Kim; Won Bae Jeon
Journal:  Food Chem Toxicol       Date:  2013-08-12       Impact factor: 6.023

10.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.

Authors:  Mark D Robinson; Davis J McCarthy; Gordon K Smyth
Journal:  Bioinformatics       Date:  2009-11-11       Impact factor: 6.937
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  4 in total

1.  Effects of perfluorooctanoic acid and perfluorooctane sulfonate on acute toxicity, superoxide dismutase, and cellulase activity in the earthworm Eisenia fetida.

Authors:  Zuoqing Yuan; Jianyong Zhang; Lili Zhao; Jing Li; Hongbin Liu
Journal:  Environ Sci Pollut Res Int       Date:  2017-06-20       Impact factor: 4.223

2.  Toxicity of perfluorooctanoic acid towards earthworm and enzymatic activities in soil.

Authors:  Wenxiang He; Mallavarapu Megharaj; Ravi Naidu
Journal:  Environ Monit Assess       Date:  2016-06-21       Impact factor: 2.513

3.  Annotation of nerve cord transcriptome in earthworm Eisenia fetida.

Authors:  Vasanthakumar Ponesakki; Sayan Paul; Dinesh Kumar Sudalai Mani; Veeraragavan Rajendiran; Paulkumar Kanniah; Sudhakar Sivasubramaniam
Journal:  Genom Data       Date:  2017-10-12

4.  Antioxidant defense system responses, lysosomal membrane stability and DNA damage in earthworms (Eisenia fetida) exposed to perfluorooctanoic acid: an integrated biomarker approach to evaluating toxicity.

Authors:  Zhifeng Wang; Chaona Li; Yuanyuan Shao; Weina Xue; Ning Wang; Xiaoming Xu; Zhibin Zhang
Journal:  RSC Adv       Date:  2021-08-03       Impact factor: 4.036
  4 in total

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