Literature DB >> 269404

Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.

H Yamasaki, E Fibach, U Nudel, I B Weinstein, R A Rifkind, P A Marks.   

Abstract

Addition of the potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to murine erythroleukemia cell lines in suspension cultures inhibited both spontaneous differentiation and differentiation induced by hexamethylene bisacetamide (HMBA), dimethyl sulfoxide, or butyric acid. Inhibition was unrelated to cytotoxicity and was reversible. When several plant diterpenes were tested, there was a positive correlation between tumor-promoting activity and inhibition of differentiation. TPA inhibited HMBA-induced differentiation only if added prior to the time of commitment to differentiation, as assayed by scoring for differentiation after transfer of cells from HMBA to fresh medium without HMBA. TPA-mediated inhibition of differentiation was associated with a decrease in globin mRNA accumulation.

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Year:  1977        PMID： 269404      PMCID： PMC431603          DOI： 10.1073/pnas.74.8.3451

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  Commitment to erythroid differentiation by friend erythroleukemia cells: a stochastic analysis.

Authors:  J Gusella; R Geller; B Clarke; V Weeks; D Housman
Journal:  Cell       Date:  1976-10       Impact factor: 41.582

2.  Induction of differentiation in mouse neuroblastoma cells by hexamethylene bisacetamide.

Authors:  C Palfrey; Y Kimhi; U Z Littauer
Journal:  Biochem Biophys Res Commun       Date:  1977-06-06       Impact factor: 3.575

3.  Surface changes in differentiating Friend erythroleukemic cells in culture.

Authors:  H Eisen; S Nasi; C P Georgopoulos; D Arndt-Jovin; W Ostertag
Journal:  Cell       Date:  1977-04       Impact factor: 41.582

4.  Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.

Authors:  G Rovera; T G O'Brien; L Diamond
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

5.  Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells.

Authors:  E Fibach; R C Reuben; R A Rifkind; P A Marks
Journal:  Cancer Res       Date:  1977-02       Impact factor: 12.701

6.  Effect of a tumour promoter on myogenesis.

Authors:  R Cohen; M Pacifici; N Rubinstein; J Biehl; H Holtzer
Journal:  Nature       Date:  1977-04-07       Impact factor: 49.962

7.  Transient inhibition of initiation of S-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation.

Authors:  M Terada; J Fried; U Nudel; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

8.  Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells.

Authors:  J Ross; Y Ikawa; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

9.  The phenotypes of variant clones of Friend mouse erythroleukemic cells resistant to dimethyl sulfoxide.

Authors:  G Rovera; J Bonaiuto
Journal:  Cancer Res       Date:  1976-11       Impact factor: 12.701

10.  Differential effects of chemical inducers on expression of beta globin genes in murine erythroleukemia cells.

Authors:  U Nudel; J E Salmon; M Terada; A Bank; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205
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  49 in total

Review 1.  The world according to Maf.

Authors:  H Motohashi; J A Shavit; K Igarashi; M Yamamoto; J D Engel
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

2.  Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate.

Authors:  P Zabos; D Kyner; N Mendelsohn; C Schreiber; S Waxman; J Christman; G Acs
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

3.  Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor.

Authors:  L S Lee; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

4.  Sialyltransferase activity as a marker for the differentiation of lymphocytes. Increase in sialyltransferase activity of blasts from acute lymphoblastic leukaemia cases by 12-o-tetradecanoylphorbol-13-acetate (TPA).

Authors:  R Sasaki; F Takaku; Y L Lin; F J Bollum
Journal:  Clin Exp Immunol       Date:  1982-02       Impact factor: 4.330

5.  Opposing effects of interferon produced in bacteria and of tumor promoters on myogenesis in human myoblast cultures.

Authors:  P B Fisher; A F Miranda; L E Babiss; S Pestka; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

6.  Continuous suppression of globin gene expression and differentiation of Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) despite the loss of PMA binding sites by down regulation.

Authors:  H Yamasaki; N Martel; A Fusco; W Ostertag
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.

Authors:  J Lotem; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

8.  Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.

Authors:  P Ralph; T Kishimoto
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

9.  Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia.

Authors:  H P Koeffler; M Bar-Eli; M Territo
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

10.  Induction and properties of beta-adrenergic receptors during erythroid differentiation of Friend leukemic cells.

Authors:  H Schmitt; M Guyaux; R Pochet; R Kram
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205
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