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Literature DB >> 268640

Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.

Abstract

Clones of Friend erythroleukemia cells, characterized by the presence of 40-70% benzidine-positive cells synthesizing hemoglobin in the absence of inducing drugs, were treated with several phorbol diesters with a known range of tumor-promoting activity on mouse skin. Good correlation was found between the reported tumor-promoting activity of a particular phorbol diester and its ability to inhibit spontaneous erythroid differentiation in culture. The inhibition of differentiation by 12-O-tetradecanoyl-phorbol-13-acetate, the most active tumor promoter, was maximum after 4 days of treatment; this inhibition was reversed by removal of the phorbol diester no matter how long the period of treatment. Unlike control cells, which gradually revert to a population with a low percentage of benzidine-positive cells, cells treated with 12-O-tetradecanoyl-phorbol-13-acetate retained a high potential for spontaneous differentiation.

Entities: Chemical Disease Species

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Year: 1977 PMID： 268640 PMCID： PMC431336 DOI： 10.1073/pnas.74.7.2894

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Differentiation in erythroleukemic cells and their somatic hybrids.

Authors: S H Orkin; F I Harosi; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. A cell culture system for the assessment of tumor-promoting activity.

Authors: A Sivak; B L Van Duuren
Journal: J Natl Cancer Inst Date: 1970-05 Impact factor: 13.506

Review 4. Studies on the control of differentiation of murine virus-induced erythroleukemic cells.

Authors: C Friend; H D Preisler; W Scher
Journal: Curr Top Dev Biol Date: 1974 Impact factor: 4.897

Review 5. Tumor-promoting agents in two-stage carcinogenesis.

Authors: B L Van Duuren
Journal: Prog Exp Tumor Res Date: 1969

6. Growth stimulation of human diploid fibro-blasts by the tumor promoter, 12-0-tetradecanoly-phorbol-13-acetate.

Authors: L Diamond; S O'Brien; C Donaldson; Y Shimizu
Journal: Int J Cancer Date: 1974-05-15 Impact factor: 7.396

7. Effect of a tumour promoter on myogenesis.

Authors: R Cohen; M Pacifici; N Rubinstein; J Biehl; H Holtzer
Journal: Nature Date: 1977-04-07 Impact factor: 49.962

8. Synthesis of erythrocyte-specific proteins in cultured friend leukemia cells.

Authors: D Kabat; C C Sherton; L H Evans; R Bigley; R D Koler
Journal: Cell Date: 1975-07 Impact factor: 41.582

9. Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.

Authors: J E Trosko; C C Chang; L P Yotti; E H Chu
Journal: Cancer Res Date: 1977-01 Impact factor: 12.701

10. The phenotypes of variant clones of Friend mouse erythroleukemic cells resistant to dimethyl sulfoxide.

Authors: G Rovera; J Bonaiuto
Journal: Cancer Res Date: 1976-11 Impact factor: 12.701

44 in total

1. Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate.

Authors: P Zabos; D Kyner; N Mendelsohn; C Schreiber; S Waxman; J Christman; G Acs
Journal: Proc Natl Acad Sci U S A Date: 1978-11 Impact factor: 11.205

2. Sialyltransferase activity as a marker for the differentiation of lymphocytes. Increase in sialyltransferase activity of blasts from acute lymphoblastic leukaemia cases by 12-o-tetradecanoylphorbol-13-acetate (TPA).

Authors: R Sasaki; F Takaku; Y L Lin; F J Bollum
Journal: Clin Exp Immunol Date: 1982-02 Impact factor: 4.330

3. Opposing effects of interferon produced in bacteria and of tumor promoters on myogenesis in human myoblast cultures.

Authors: P B Fisher; A F Miranda; L E Babiss; S Pestka; I B Weinstein
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

4. Continuous suppression of globin gene expression and differentiation of Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) despite the loss of PMA binding sites by down regulation.

Authors: H Yamasaki; N Martel; A Fusco; W Ostertag
Journal: Proc Natl Acad Sci U S A Date: 1984-04 Impact factor: 11.205

5. Effects of n-butyrate and phorbol ester (TPA) on induction of Epstein-Barr virus antigens and cell differentiation.

Authors: E Anisimová; K Prachová; J Roubal; V Vonka
Journal: Arch Virol Date: 1984 Impact factor: 2.574

6. Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.

Authors: J Lotem; L Sachs
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

7. 12-O-Tetradecanoylphorbol-13-acetate (TPA) directly inhibits spontaneous immunoglobulin secretion by in vivo antigen-induced human lymphoblastoid B cells.

Authors: J A Brieva; J S Louie; R H Stevens
Journal: J Clin Immunol Date: 1984-07 Impact factor: 8.317

8. Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.

Authors: P Ralph; T Kishimoto
Journal: J Clin Invest Date: 1981-10 Impact factor: 14.808

9. Antagonism between epidermal growth factor and phorbol ester tumor promoters in human breast cancer cells.

Authors: C K Osborne; B Hamilton; M Nover; J Ziegler
Journal: J Clin Invest Date: 1981-04 Impact factor: 14.808

10. Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia.

Authors: H P Koeffler; M Bar-Eli; M Territo
Journal: J Clin Invest Date: 1980-11 Impact factor: 14.808