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Literature DB >> 269387

Physical properties of chemically acetylated rat liver chromatin.

R B Wallace, T D Sargent, R F Murphy, J Bonner.

Abstract

The physical properties of rat liver chromatin and nucleosomes acetylated with acetic anhydride were examined in order to clarify the mechanism by which chemical acetylation of histones increases template activity in vitro [Marushige, K. (1976) Proc. Natl. Acad. Sci. USA 73, 3937-3941]. Acetylation was found to have dramatic effects on the magnesium solubility, nuclease sensitivity, thermal denaturation, and sedimentation of chromatin and nucleosomes. The significance of the results to models of gene activation and chromatin replication is considered.

Entities: Chemical Species

Mesh：

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Year: 1977 PMID： 269387 PMCID： PMC431516 DOI： 10.1073/pnas.74.8.3244

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.

Authors: V G ALLFREY; R FAULKNER; A E MIRSKY
Journal: Proc Natl Acad Sci U S A Date: 1964-05 Impact factor: 11.205

2. PHYSICAL AND BIOLOGICAL PROPERTIES OF SOLUBLE NUCLEOHISTONES.

Authors: R CHIH; C HUANG; J BONNER; K MURRAY
Journal: J Mol Biol Date: 1964-01 Impact factor: 5.469

3. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

Authors: A Garel; R Axel
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

4. Activation of chromatin by acetylation of histone side chains.

Authors: K Marushige
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

5. Ribosomal genes of Xenopus laevis: evidence of nucleosomes in transcriptionally active chromatin.

Authors: R Reeves
Journal: Science Date: 1976-10-29 Impact factor: 47.728

6. Chromatin structure as probed by nucleases and proteases: evidence for the central role of histones H3 and H4.

Authors: B Sollner-Webb; R D Camerini-Otero; G Felsenfeld
Journal: Cell Date: 1976-09 Impact factor: 41.582

7. Chromosomal subunits in active genes have an altered conformation.

Authors: H Weintraub; M Groudine
Journal: Science Date: 1976-09-03 Impact factor: 47.728

8. Interaction of lysine-rich histones and DNA.

Authors: D E Olins
Journal: J Mol Biol Date: 1969-08-14 Impact factor: 5.469

9. Partial purification of the template-active fraction of chromatin: a preliminary report.

Authors: J M Gottesfeld; W T Garrard; G Bagi; R F Wilson; J Bonner
Journal: Proc Natl Acad Sci U S A Date: 1974-06 Impact factor: 11.205

10. Characterization of macromolecules by constant velocity sedimentation.

Authors: H Noll
Journal: Nature Date: 1967-07-22 Impact factor: 49.962

11 in total

Review 1. Advances in chromatin research.

Authors: J Sonnenbichler
Journal: Naturwissenschaften Date: 1979-05

Physical properties of chemically acetylated rat liver chromatin.

1. ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.

2. PHYSICAL AND BIOLOGICAL PROPERTIES OF SOLUBLE NUCLEOHISTONES.

3. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

4. Activation of chromatin by acetylation of histone side chains.

5. Ribosomal genes of Xenopus laevis: evidence of nucleosomes in transcriptionally active chromatin.

6. Chromatin structure as probed by nucleases and proteases: evidence for the central role of histones H3 and H4.

7. Chromosomal subunits in active genes have an altered conformation.

8. Interaction of lysine-rich histones and DNA.

9. Partial purification of the template-active fraction of chromatin: a preliminary report.

10. Characterization of macromolecules by constant velocity sedimentation.

Review 1. Advances in chromatin research.

2. Altered nucleosome spacing in newly replicated chromatin from Friend leukemia cells.

3. Fine structure and evolution of the rat serum albumin gene.

Review 4. Acetylation of histones in nucleosomes.

5. Computer programs for analysis of nucleic acid hybridization, thermal denaturation, and gel electrophoresis data.

6. The variation with age of the structure of chromatin in three cell types from rat liver.

7. Pitfalls in the use of carboxylic acid anhydrides for structural studies of nucleoprotein particles.

Review 8. Effects of sodium butyrate, a new pharmacological agent, on cells in culture.

9. Chromatin structure in the cellular slime mold Dictyostelium discoideum.

10. β- and γ-Actins in the nucleus of human melanoma A375 cells.