Literature DB >> 26938436

Novel PAMs Targeting NMDAR GluN2A Subunit.

Zixiu Xiang1, P Jeffrey Conn2.   

Abstract

In this issue of Neuron, Hackos et al. (2016) report the discovery of novel positive allosteric modulators that are highly selective for GluN2A-containing NMDA receptors. This novel class of PAMs shows distinct effects on synaptic plasticity.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26938436      PMCID： PMC4793964          DOI： 10.1016/j.neuron.2016.02.025

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  16 in total

1.  CP-101,606, a potent neuroprotectant selective for forebrain neurons.

Authors:  F Menniti; B Chenard; M Collins; M Ducat; I Shalaby; F White
Journal:  Eur J Pharmacol       Date:  1997-07-23       Impact factor: 4.432

2.  An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors.

Authors:  Enrique Jambrina; Rok Cerne; Emery Smith; Louis Scampavia; Maria Cuadrado; Jeremy Findlay; Michael J Krambis; Mark Wakulchik; Peter Chase; Michael Brunavs; Kevin D Burris; Peter Gallagher; Timothy P Spicer; Daniel Ursu
Journal:  J Biomol Screen       Date:  2016-02-02

3.  Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.

Authors:  M Yue; K M Hinkle; P Davies; E Trushina; F C Fiesel; T A Christenson; A S Schroeder; L Zhang; E Bowles; B Behrouz; S J Lincoln; J E Beevers; A J Milnerwood; A Kurti; P J McLean; J D Fryer; W Springer; D W Dickson; M J Farrer; H L Melrose
Journal:  Neurobiol Dis       Date:  2015-03-31       Impact factor: 5.996

4.  Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.

Authors:  Jerri M Rook; Zixiu Xiang; Xiaohui Lv; Ayan Ghoshal; Jonathan W Dickerson; Thomas M Bridges; Kari A Johnson; Daniel J Foster; Karen J Gregory; Paige N Vinson; Analisa D Thompson; Nellie Byun; Rebekah L Collier; Michael Bubser; Michael T Nedelcovych; Robert W Gould; Shaun R Stauffer; J Scott Daniels; Colleen M Niswender; Hilde Lavreysen; Claire Mackie; Susana Conde-Ceide; Jesus Alcazar; José M Bartolomé-Nebreda; Gregor J Macdonald; John C Talpos; Thomas Steckler; Carrie K Jones; Craig W Lindsley; P Jeffrey Conn
Journal:  Neuron       Date:  2015-04-30       Impact factor: 17.173

5.  Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.

Authors:  Rose M Santangelo Freel; Kevin K Ogden; Katie L Strong; Alpa Khatri; Kathryn M Chepiga; Henrik S Jensen; Stephen F Traynelis; Dennis C Liotta
Journal:  J Med Chem       Date:  2013-06-20       Impact factor: 7.446

6.  Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

Authors:  David H Hackos; Patrick J Lupardus; Teddy Grand; Yelin Chen; Tzu-Ming Wang; Paul Reynen; Amy Gustafson; Heidi J A Wallweber; Matthew Volgraf; Benjamin D Sellers; Jacob B Schwarz; Pierre Paoletti; Morgan Sheng; Qiang Zhou; Jesse E Hanson
Journal:  Neuron       Date:  2016-02-11       Impact factor: 17.173

7.  A novel family of negative and positive allosteric modulators of NMDA receptors.

Authors:  Blaise Mathias Costa; Mark W Irvine; Guangyu Fang; Richard J Eaves; Marie Belen Mayo-Martin; Donald A Skifter; David E Jane; Daniel T Monaghan
Journal:  J Pharmacol Exp Ther       Date:  2010-09-21       Impact factor: 4.030

8.  Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

Authors:  K Sakimura; T Kutsuwada; I Ito; T Manabe; C Takayama; E Kushiya; T Yagi; S Aizawa; Y Inoue; H Sugiyama
Journal:  Nature       Date:  1995-01-12       Impact factor: 49.962

9.  Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

Authors:  K Williams
Journal:  Mol Pharmacol       Date:  1993-10       Impact factor: 4.436

10.  Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

Authors:  Sommer S Zimmerman; Alpa Khatri; Ethel C Garnier-Amblard; Praseeda Mullasseril; Natalie L Kurtkaya; Stefka Gyoneva; Kasper B Hansen; Stephen F Traynelis; Dennis C Liotta
Journal:  J Med Chem       Date:  2014-02-25       Impact factor: 7.446
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  3 in total

Review 1.  The Role of GluN2A in Cerebral Ischemia: Promoting Neuron Death and Survival in the Early Stage and Thereafter.

Authors:  Yongjun Sun; Xiaokun Cheng; Jie Hu; Zibin Gao
Journal:  Mol Neurobiol       Date:  2017-01-19       Impact factor: 5.590

Review 2.  Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators.

Authors:  Menghan Niu; Xin Yang; Yuanyuan Li; Yanping Sun; Long Wang; Jing Ha; Yinghua Xie; Zibin Gao; Changzheng Tian; Le Wang; Yongjun Sun
Journal:  Cell Mol Neurobiol       Date:  2022-01-03       Impact factor: 5.046

Review 3.  The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.

Authors:  Iulia Zoicas; Johannes Kornhuber
Journal:  Int J Mol Sci       Date:  2019-11-09       Impact factor: 5.923
  3 in total

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