| Literature DB >> 34978648 |
Menghan Niu1, Xin Yang2,3, Yuanyuan Li1, Yanping Sun1,4,5, Long Wang6, Jing Ha1, Yinghua Xie1, Zibin Gao1,4,5, Changzheng Tian7, Le Wang8,9, Yongjun Sun10,11,12.
Abstract
NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing NMDA receptors as well as selective GluN2A regulators were described to further understand this type of NMDA receptors.Entities:
Keywords: Expression; Function properties GluN2A-selective regulators; GluN2A-containing NMDA receptors
Year: 2022 PMID： 34978648 DOI： 10.1007/s10571-021-01185-1
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046