Hiroshi Makino1, Shin Nishio2, Hiroshi Tsubamoto3, Muneaki Shimada4, Ryutaro Nishikawa5, Kentaro Kai6, Kimihiko Ito7, Tomoko Mizuno1, Kimio Ushijima2, Ken-Ichiro Morishige1. 1. Department of Obstetrics and Gynecology, Gifu University, Gifu, Japan. 2. Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan. 3. Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Japan. 4. Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan. 5. Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, Nagoya, Japan. 6. Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Yufu, Japan. 7. Department of Obstetrics and Gynecology, Kansai Rosai Hospital, Amagasaki, Japan.
Abstract
AIM: The early and precise diagnosis and proper palliative treatment of bone metastasis is important for improving the quality of life of cervical cancer patients. The aim of this study was to clarify the clinical features, treatment modalities and prognosis of bone metastasis in cervical cancer patients in Japan. METHODS: The medical records of 75 cervical cancer patients with bone metastasis who were treated between January 2000 and December 2010 were retrospectively analyzed in a multi-institutional study. RESULTS: Fifty-four patients (72.0%) had a single bone metastasis. Bone metastases were found in the spine (46.7%) and pelvis (42.7%). Forty-three patients (57.3%) also had extra-osseous metastases. Most of the patients received radiotherapy, chemotherapy or both, but 25 patients (33.3%) received palliative care only. Bisphosphonates were given as palliative therapy to 25 patients (33.3%). The median overall survival after the diagnosis of bone metastasis was significantly shorter in patients with extra-osseous metastases than in those without extra-osseous metastases (14 vs 5 months; P < 0.05). The survival of patients who received chemotherapy following radiotherapy or concurrent chemoradiotherapy was significantly longer than that of the patients who received palliative care. On multivariate analysis, the presence of extra-osseous metastasis was an independent predictor of survival in patients with bone metastasis from cervical cancer. CONCLUSIONS: Multidisciplinary treatment might improve the prognosis of patients with bone metastasis who do not have extra-osseous lesions.
AIM: The early and precise diagnosis and proper palliative treatment of bone metastasis is important for improving the quality of life of cervical cancerpatients. The aim of this study was to clarify the clinical features, treatment modalities and prognosis of bone metastasis in cervical cancerpatients in Japan. METHODS: The medical records of 75 cervical cancerpatients with bone metastasis who were treated between January 2000 and December 2010 were retrospectively analyzed in a multi-institutional study. RESULTS: Fifty-four patients (72.0%) had a single bone metastasis. Bone metastases were found in the spine (46.7%) and pelvis (42.7%). Forty-three patients (57.3%) also had extra-osseous metastases. Most of the patients received radiotherapy, chemotherapy or both, but 25 patients (33.3%) received palliative care only. Bisphosphonates were given as palliative therapy to 25 patients (33.3%). The median overall survival after the diagnosis of bone metastasis was significantly shorter in patients with extra-osseous metastases than in those without extra-osseous metastases (14 vs 5 months; P < 0.05). The survival of patients who received chemotherapy following radiotherapy or concurrent chemoradiotherapy was significantly longer than that of the patients who received palliative care. On multivariate analysis, the presence of extra-osseous metastasis was an independent predictor of survival in patients with bone metastasis from cervical cancer. CONCLUSIONS: Multidisciplinary treatment might improve the prognosis of patients with bone metastasis who do not have extra-osseous lesions.
Authors: Jingyuan Wang; Yibo Dai; Tao Ji; Wei Guo; Zhiqi Wang; Jianliu Wang Journal: Int J Environ Res Public Health Date: 2022-06-02 Impact factor: 4.614