Literature DB >> 2693479

Growth properties of human herpesvirus-6 strain Z29.

J B Black1, K C Sanderlin, C S Goldsmith, H E Gary, C Lopez, P E Pellett.   

Abstract

Experiments performed to optimize the growth conditions of HHV-6(Z29) revealed that the virus grows best in phytohemagglutinin-stimulated umbilical cord blood lymphocytes (CBL) cultured in media containing 32 units/ml interleukin-2 and 0.01 mg/ml hydrocortisone. The titer of maternal antibody in the plasma of the cord blood cells does not affect the ability of the cells to support virus growth. DEAE-dextran and polybrene do not increase virus growth in umbilical cord blood lymphocytes. Phorbol myristate acetate abolishes virus growth. The HHV-6(Z29) growth cycle in CBL was approximately 5 days; capsids were not seen before day 3, and mature virions were not seen before day 5.

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Year:  1989        PMID： 2693479     DOI： 10.1016/0166-0934(89)90143-2

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  18 in total

Review 1.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

2.  Differentiation between two distinct classes of viruses now classified as human herpesvirus 6.

Authors:  E C Schirmer; L S Wyatt; K Yamanishi; W J Rodriguez; N Frenkel
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

3.  Temporal mapping of transcripts in herpesvirus 6 variants.

Authors:  P Mirandola; P Menegazzi; S Merighi; T Ravaioli; E Cassai; D Di Luca
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

4.  Infection of human T lymphocytes with varicella-zoster virus: an analysis with viral mutants and clinical isolates.

Authors:  W Soong; J C Schultz; A C Patera; M H Sommer; J I Cohen
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

Review 5.  Update on human herpesvirus 6 biology, clinical features, and therapy.

Authors:  Leen De Bolle; Lieve Naesens; Erik De Clercq
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

6.  Coinfection with human herpesvirus 6 variants A and B in lung tissue.

Authors:  R W Cone; M L Huang; R C Hackman; L Corey
Journal:  J Clin Microbiol       Date:  1996-04       Impact factor: 5.948

7.  Mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 ORF 65-encoded protein.

Authors:  C P Pau; L L Lam; T J Spira; J B Black; J A Stewart; P E Pellett; R A Respess
Journal:  J Clin Microbiol       Date:  1998-06       Impact factor: 5.948

8.  Human herpesvirus type 6 indirectly enhances oligodendrocyte cell death.

Authors:  Hong Kong; Quinton Baerbig; Laine Duncan; Nick Shepel; Michael Mayne
Journal:  J Neurovirol       Date:  2003-10       Impact factor: 2.643

9.  Transactivation of the human immunodeficiency virus promoter by human herpesvirus 6 (HHV-6) strains GS and Z-29 in primary human T lymphocytes and identification of transactivating HHV-6(GS) gene fragments.

Authors:  R T Horvat; C Wood; S F Josephs; N Balachandran
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

10.  Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals.

Authors:  R W Cone; M L Huang; R Ashley; L Corey
Journal:  J Clin Microbiol       Date:  1993-05       Impact factor: 5.948
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