Literature DB >> 9620379

Mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 ORF 65-encoded protein.

C P Pau1, L L Lam, T J Spira, J B Black, J A Stewart, P E Pellett, R A Respess.   

Abstract

A dominant epitope within the human herpesvirus 8 (HHV8) ORF 65-encoded protein was mapped to an 8-amino-acid (aa) sequence (RKPPSGKK [aa 162 to 169]) by an amino acid replacement method. Using a 14-aa peptide (P4) encompassing this epitope as the antigen, we developed an enzyme immunoassay for HHV8 antibodies. The presence of P4 antibodies in a panel of 61 human serum specimens was highly correlated with biopsy-confirmed Kaposi's sarcoma. The homologous Epstein-Barr virus peptide derived from BFBR3-encoded protein did not interfere with the assay, suggesting that P4 is specific for HHV8.

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Year:  1998        PMID： 9620379      PMCID： PMC104879     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  23 in total

1.  Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates.

Authors:  D M Koelle; M L Huang; B Chandran; J Vieira; M Piepkorn; L Corey
Journal:  J Infect Dis       Date:  1997-07       Impact factor: 5.226

2.  Presence of human herpesvirus 8 variants in the oral tissues of human immunodeficiency virus-infected persons.

Authors:  L Di Alberti; S L Ngui; S R Porter; P M Speight; C M Scully; J M Zakrewska; I G Williams; L Artese; A Piattelli; C G Teo
Journal:  J Infect Dis       Date:  1997-03       Impact factor: 5.226

Review 3.  HHV-8: a new herpesvirus associated with Kaposi's sarcoma.

Authors:  M K Offermann
Journal:  Trends Microbiol       Date:  1996-10       Impact factor: 17.079

4.  Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate.

Authors:  J C Zong; C Metroka; M S Reitz; J Nicholas; G S Hayward
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

5.  Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors.

Authors:  M R Howard; D Whitby; G Bahadur; F Suggett; C Boshoff; M Tenant-Flowers; T F Schulz; S Kirk; S Matthews; I V Weller; R S Tedder; R A Weiss
Journal:  AIDS       Date:  1997-02       Impact factor: 4.177

6.  Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).

Authors:  J J Russo; R A Bohenzky; M C Chien; J Chen; M Yan; D Maddalena; J P Parry; D Peruzzi; I S Edelman; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

7.  Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen.

Authors:  G R Simpson; T F Schulz; D Whitby; P M Cook; C Boshoff; L Rainbow; M R Howard; S J Gao; R A Bohenzky; P Simmonds; C Lee; A de Ruiter; A Hatzakis; R S Tedder; I V Weller; R A Weiss; P S Moore
Journal:  Lancet       Date:  1996-10-26       Impact factor: 79.321

8.  Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi's sarcoma by polymerase chain reaction in situ hybridization.

Authors:  Y Q Huang; J J Li; B J Poiesz; M H Kaplan; A E Friedman-Kien
Journal:  Am J Pathol       Date:  1997-01       Impact factor: 4.307

9.  The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women.

Authors:  D H Kedes; D Ganem; N Ameli; P Bacchetti; R Greenblatt
Journal:  JAMA       Date:  1997-02-12       Impact factor: 56.272

10.  Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus-specific peptide.

Authors:  D A Davis; R W Humphrey; F M Newcomb; T R O'Brien; J J Goedert; S E Straus; R Yarchoan
Journal:  J Infect Dis       Date:  1997-05       Impact factor: 5.226
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  23 in total

1.  Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection.

Authors:  T J Spira; L Lam; S C Dollard; Y X Meng; C P Pau; J B Black; D Burns; B Cooper; M Hamid; J Huong; K Kite-Powell; P E Pellett
Journal:  J Clin Microbiol       Date:  2000-06       Impact factor: 5.948

2.  Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies.

Authors:  J N Martin; Z Amad; C Cossen; P K Lam; D H Kedes; K A Page-Shafer; D H Osmond; B Forghani
Journal:  J Clin Microbiol       Date:  2000-02       Impact factor: 5.948

3.  Identification and expression of immunogenic proteins of a disease-associated marine turtle herpesvirus.

Authors:  Sadie S Coberley; Richard C Condit; Lawrence H Herbst; Paul A Klein
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

4.  Sex and geographic patterns of human herpesvirus 8 infection in a nationally representative population‐based sample in Uganda.

Authors:  Benon Biryahwaho; Sheila C Dollard; Ruth M Pfeiffer; Fatma M Shebl; Stella Munuo; Minal M Amin; Wolfgang Hladik; Ruth Parsons; Sam M Mbulaiteye
Journal:  J Infect Dis       Date:  2010-11-01       Impact factor: 5.226

5.  Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection.

Authors:  Patrick Unemori; Kieron S Leslie; Peter W Hunt; Elizabeth Sinclair; Lorrie Epling; Ronald Mitsuyasu; Rita B Effros; Jeffrey Dock; Sheila G Dollard; Steven G Deeks; Jeffrey N Martin; Toby A Maurer
Journal:  AIDS       Date:  2013-07-17       Impact factor: 4.177

6.  Highly sensitive assay for human herpesvirus 8 antibodies that uses a multiple antigenic peptide derived from open reading frame K8.1.

Authors:  Lee L Lam; Chou-Pong Pau; Sheila C Dollard; Philip E Pellett; Thomas J Spira
Journal:  J Clin Microbiol       Date:  2002-02       Impact factor: 5.948

7.  Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection.

Authors:  A Scott Laney; Jonathan S Peters; Susan M Manzi; Lawrence A Kingsley; Yuan Chang; Patrick S Moore
Journal:  J Clin Microbiol       Date:  2006-10       Impact factor: 5.948

8.  Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt".

Authors:  Sheila C Dollard; Lisa M Butler; Alison M Graves Jones; Jonathan H Mermin; Midion Chidzonga; Tsungai Chipato; Caroline H Shiboski; Christian Brander; Anisa Mosam; Photini Kiepiela; Wolfgang Hladik; Jeffrey N Martin
Journal:  Int J Cancer       Date:  2010-11-15       Impact factor: 7.396

9.  Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques.

Authors:  Jonathan T Ryan; Timothy M Rose
Journal:  Clin Vaccine Immunol       Date:  2013-01-23

10.  Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.

Authors:  Lisa M Butler; Grant Dorsey; Wolfgang Hladik; Philip J Rosenthal; Christian Brander; Torsten B Neilands; Georgina Mbisa; Denise Whitby; Photini Kiepiela; Anisa Mosam; Similo Mzolo; Sheila C Dollard; Jeffrey N Martin
Journal:  J Infect Dis       Date:  2009-08-01       Impact factor: 5.226
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