Literature DB >> 26928318

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis.

Zuzana Drobná1, Elizabeth Martin2, Kyung Su Kim3, Lisa Smeester2, Paige Bommarito2, Marisela Rubio-Andrade4, Gonzalo G García-Vargas4, Miroslav Stýblo5, Fei Zou3, Rebecca C Fry6.   

Abstract

Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the metabolism of inorganic arsenic (iAs). Polymorphisms of AS3MT influence adverse health effects in adults, but little is known about their role in iAs metabolism in pregnant women and infants. The relationships between seven single nucleotide polymorphisms (SNPs) in AS3MT and urinary concentrations of iAs and its methylated metabolites were assessed in mother-infant pairs of the Biomarkers of Exposure to ARsenic (BEAR) cohort. Maternal alleles for five of the seven SNPs (rs7085104, rs3740400, rs3740393, rs3740390, and rs1046778) were associated with urinary concentrations of iAs metabolites, and alleles for one SNP (rs3740393) were associated with birth outcomes/measures. These associations were strongly dependent upon the male sex of the fetus but independent of fetal genotype for AS3MT. These data highlight a potential sex-dependence of the relationships among maternal genotype, iAs metabolism and infant health outcomes.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  AS3MT; Arsenic; Birth outcomes; Genotype; Prenatal exposure

Mesh：

Substances：

Year:  2016        PMID： 26928318      PMCID： PMC4970429          DOI： 10.1016/j.reprotox.2016.02.017

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN： 0890-6238            Impact factor:   3.143


  51 in total

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