Literature DB >> 26924283

Fabrication of biodegradable PEG-PLA nanospheres for solubility, stabilization, and delivery of curcumin.

Hongying Liang1, Joel M Friedman1, Parimala Nacharaju1.   

Abstract

Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)-poly (lactic acid) (PEG-PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

Entities:  

Keywords:  Curcumin; drug delivery; nanospheres; poly(ethylene glycol)–poly(lactic acid)

Mesh：

Substances：

Year:  2016        PMID： 26924283     DOI： 10.3109/21691401.2016.1146736

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  4 in total

Review 1.  Advances and limitations of drug delivery systems formulated as eye drops.

Authors:  Clotilde Jumelle; Shima Gholizadeh; Nasim Annabi; Reza Dana
Journal:  J Control Release       Date:  2020-02-03       Impact factor: 9.776

Review 2.  Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Authors:  Wamidh H Talib; Izzeddin Alsalahat; Safa Daoud; Reem Fawaz Abutayeh; Asma Ismail Mahmod
Journal:  Molecules       Date:  2020-11-14       Impact factor: 4.411

Review 3.  Nanocurcumin: A Promising Candidate for Therapeutic Applications.

Authors:  Adhimoolam Karthikeyan; Natesan Senthil; Taesun Min
Journal:  Front Pharmacol       Date:  2020-05-01       Impact factor: 5.810

Review 4.  Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers.

Authors:  Md Tanvir Kabir; Md Habibur Rahman; Rokeya Akter; Tapan Behl; Deepak Kaushik; Vineet Mittal; Parijat Pandey; Muhammad Furqan Akhtar; Ammara Saleem; Ghadeer M Albadrani; Mohamed Kamel; Shaden A M Khalifa; Hesham R El-Seedi; Mohamed M Abdel-Daim
Journal:  Biomolecules       Date:  2021-03-07
  4 in total

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