Literature DB >> 26923676

Hairpin ribozyme mediated RNA recombination.

Robert Hieronymus1, Simon Peter Godehard1, Darko Balke1, Sabine Müller1.   

Abstract

We have engineered a hairpin ribozyme that in a two-step reaction supports RNA recombination by catalysing the cleavage of two non-functional RNA precursors (first step) followed by the recombination of two of the cleavage fragments into a functional RNA (second step). The recombination product (yield: 76%) is a fully functional hammerhead ribozyme.

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Year:  2016        PMID： 26923676     DOI： 10.1039/c6cc00383d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Enhanced Ribozyme-Catalyzed Recombination and Oligonucleotide Assembly in Peptide-RNA Condensates.

Authors:  Kristian Le Vay; Emilie Yeonwha Song; Basusree Ghosh; T-Y Dora Tang; Hannes Mutschler
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-09       Impact factor: 16.823

Review 2.  Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?

Authors:  Sabine Müller; Bettina Appel; Darko Balke; Robert Hieronymus; Claudia Nübel
Journal:  F1000Res       Date:  2016-06-27

3.  RNA self-splicing by engineered hairpin ribozyme variants.

Authors:  Robert Hieronymus; Jikang Zhu; Sabine Müller
Journal:  Nucleic Acids Res       Date:  2022-01-11       Impact factor: 16.971

4.  Prebiotically Plausible RNA Activation Compatible with Ribozyme-Catalyzed Ligation.

Authors:  Emilie Yeonwha Song; Eddy Ivanhoe Jiménez; Huacan Lin; Kristian Le Vay; Ramanarayanan Krishnamurthy; Hannes Mutschler
Journal:  Angew Chem Int Ed Engl       Date:  2020-12-10       Impact factor: 16.823
  4 in total

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