Literature DB >> 26922229

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents.

Mei-Lin Tang1, Chen Zhong1, Zheng-Yu Liu1, Peng Peng1, Xin-Hua Liu2, Xun Sun3.   

Abstract

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anti-inflammatory; Indanone; TLR4/JNK/NF-κB

Mesh：

Substances：

Year:  2016        PMID： 26922229     DOI： 10.1016/j.ejmech.2016.02.021

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

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Authors:  Qin Li; Juping Zhang; Liu Zeng Chen; Jie Quan Wang; Hai Ping Zhou; Wen Jian Tang; Wei Xue; Xin Hua Liu
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

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  7 in total

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