Kelvin K W To1, Susanna K P Lau1, Kwok-Hei Chan2, Ka-Yi Mok2, Hayes K H Luk2, Cyril C Y Yip2, Yat-Kwan Ma2, Lorraine H Y Sinn3, Sonia H Y Lam3, Chun-Wai Ngai4, Ivan F N Hung5, Kwok-Hung Chan1, Kwok-Yung Yuen6. 1. State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region. 2. Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region. 3. Department of Radiology, Queen Mary Hospital, Hong Kong Special Administrative Region. 4. Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong Special Administrative Region. 5. State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; Department of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. 6. State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: kyyuen@hku.hk.
Abstract
BACKGROUND: Human rhinovirus (HRV) is frequently detected in patients with respiratory tract infection. However, the full clinical spectrum of HRV infection in critically ill patients is not well characterized. OBJECTIVE: To evaluate the clinical and virological characteristics of critically ill patients with HRV infection. STUDY DESIGN: HRV-specific reverse transcription-polymerase chain reaction (RT-PCR) was performed on nasopharyngeal aspirate (NPA) specimens from 294 adult patients who required admission into the intensive care unit (ICU). Clinical characteristics were analyzed. HRV genotyping using the 5'UTR-VP4-VP2 region was performed. RESULTS: HRV was detected in NPA specimens of 22 patients (7.5%) by RT-PCR. Dyspnea was the most common presenting symptom (16/22; 72.7%), but seizure also occurred in 5 (22.7%) patients. Exacerbation of underlying disease occurred in 12 (54.5%) patients. Four (18.2%) patients died, and HRV was considered to play a role as the cause of death in 3 patients. Thirteen (59.1%) patients had pneumonia, and the most common radiological finding was consolidation (6/13; 46.2%). Streptococcus pneumoniae was the most common co-pathogen among patients with pneumonia. Among the 9 patients without pneumonia, 3 patients had exacerbation of underlying lung diseases, 3 patients had acute pulmonary edema, 2 patients with diabetes mellitus had acute complications from poor glycemic control, and 1 patient had status epilepticus. HRV-A was the most common species (64.3%), but there was no clear relationship between HRV species and clinical presentation. CONCLUSION: Both pulmonary and extrapulmonary complications of HRV were common in critically ill patients.
BACKGROUND:Human rhinovirus (HRV) is frequently detected in patients with respiratory tract infection. However, the full clinical spectrum of HRV infection in critically illpatients is not well characterized. OBJECTIVE: To evaluate the clinical and virological characteristics of critically illpatients with HRV infection. STUDY DESIGN:HRV-specific reverse transcription-polymerase chain reaction (RT-PCR) was performed on nasopharyngeal aspirate (NPA) specimens from 294 adult patients who required admission into the intensive care unit (ICU). Clinical characteristics were analyzed. HRV genotyping using the 5'UTR-VP4-VP2 region was performed. RESULTS:HRV was detected in NPA specimens of 22 patients (7.5%) by RT-PCR. Dyspnea was the most common presenting symptom (16/22; 72.7%), but seizure also occurred in 5 (22.7%) patients. Exacerbation of underlying disease occurred in 12 (54.5%) patients. Four (18.2%) patients died, and HRV was considered to play a role as the cause of death in 3 patients. Thirteen (59.1%) patients had pneumonia, and the most common radiological finding was consolidation (6/13; 46.2%). Streptococcus pneumoniae was the most common co-pathogen among patients with pneumonia. Among the 9 patients without pneumonia, 3 patients had exacerbation of underlying lung diseases, 3 patients had acute pulmonary edema, 2 patients with diabetes mellitus had acute complications from poor glycemic control, and 1 patient had status epilepticus. HRV-A was the most common species (64.3%), but there was no clear relationship between HRV species and clinical presentation. CONCLUSION: Both pulmonary and extrapulmonary complications of HRV were common in critically illpatients.
Authors: Jonathan H K Chen; Ho-Yin Lam; Cyril C Y Yip; Sally C Y Wong; Jasper F W Chan; Edmond S K Ma; Vincent C C Cheng; Bone S F Tang; Kwok-Yung Yuen Journal: J Clin Microbiol Date: 2016-04-27 Impact factor: 5.948
Authors: Ivan F N Hung; Anna Jinxia Zhang; Kelvin K W To; Jasper F W Chan; Shawn H S Zhu; Ricky Zhang; Tuen-Ching Chan; Kwok-Hung Chan; Kwok-Yung Yuen Journal: Int J Mol Sci Date: 2017-01-26 Impact factor: 5.923
Authors: Paraskevi C Fragkou; Charalampos D Moschopoulos; Emmanouil Karofylakis; Theodoros Kelesidis; Sotirios Tsiodras Journal: Front Med (Lausanne) Date: 2021-02-23
Authors: Thrimendra Kaushika Dissanayake; Sascha Schäuble; Mohammad Hassan Mirhakkak; Wai-Lan Wu; Anthony Chin-Ki Ng; Cyril C Y Yip; Albert García López; Thomas Wolf; Man-Lung Yeung; Kwok-Hung Chan; Kwok-Yung Yuen; Gianni Panagiotou; Kelvin Kai-Wang To Journal: Front Microbiol Date: 2020-07-21 Impact factor: 5.640