James F Sumowski1, Maria A Rocca2, Victoria M Leavitt3, Gianna Riccitelli4, Alessandro Meani4, Giancarlo Comi5, Massimo Filippi2. 1. Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, USA/Manhattan Memory Center, New York, NY, USA jfs2013@columbia.edu. 2. Neuroimaging Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 3. Department of Neurology, Columbia University Medical Center, New York, NY, USA. 4. Neuroimaging Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 5. Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Abstract
BACKGROUND: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). OBJECTIVE: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. METHODS: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. RESULTS: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). CONCLUSIONS: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.
BACKGROUND: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). OBJECTIVE: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. METHODS: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MSpatients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. RESULTS: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). CONCLUSIONS: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.
Authors: J F Sumowski; M A Rocca; V M Leavitt; G Riccitelli; J Sandry; J DeLuca; G Comi; M Filippi Journal: Eur J Neurol Date: 2015-02-04 Impact factor: 6.089
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Authors: P S Eriksson; E Perfilieva; T Björk-Eriksson; A M Alborn; C Nordborg; D A Peterson; F H Gage Journal: Nat Med Date: 1998-11 Impact factor: 53.440
Authors: James F Sumowski; Maria A Rocca; Victoria M Leavitt; Gianna Riccitelli; Giancarlo Comi; John DeLuca; Massimo Filippi Journal: Neurology Date: 2013-05-10 Impact factor: 9.910
Authors: Kimberly G Noble; Stuart M Grieve; Mayuresh S Korgaonkar; Laura E Engelhardt; Erica Y Griffith; Leanne M Williams; Adam M Brickman Journal: Front Hum Neurosci Date: 2012-11-09 Impact factor: 3.169