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Literature DB >> 26919685

Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.

Jie Hao¹, Kenneth C K Cheng², Laura G Kruger¹, Lena Larsson^1,3, James V Sugai¹, Joerg Lahann⁴, William V Giannobile⁵.

Abstract

Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.

Entities: CellLine Chemical Disease Gene Species

Keywords: bone morphogenetic proteins; drug delivery; gene transfer; platelet-derived growth factor; regenerative medicine; tissue regeneration

Mesh：

Substances：

Year: 2016 PMID： 26919685 PMCID： PMC5687504 DOI： 10.1002/adma.201600027

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

22 in total

1. Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo.

Authors: Eiji Saito; Elly E Liao; Wei-Wen Hu; Paul H Krebsbach; Scott J Hollister
Journal: J Tissue Eng Regen Med Date: 2011-12-09 Impact factor: 3.963

2. Cellular transduction gradients via vapor-deposited polymer coatings.

Authors: Yaseen M Elkasabi; Joerg Lahann; Paul H Krebsbach
Journal: Biomaterials Date: 2010-12-22 Impact factor: 12.479

3. Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use.

Authors: Po-Chun Chang; Joni A Cirelli; Qiming Jin; Yang-Jo Seol; James V Sugai; Nisha J D'Silva; Theodora E Danciu; Lois A Chandler; Barbara A Sosnowski; William V Giannobile
Journal: Hum Gene Ther Date: 2009-05 Impact factor: 5.695

4. In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease.

Authors: Pengcheng Zhang; Lingli Chen; Wangwen Gu; Zhenghong Xu; Yu Gao; Yaping Li
Journal: Biomaterials Date: 2006-12-28 Impact factor: 12.479

5. The effects of Runx2 immobilization on poly (epsilon-caprolactone) on osteoblast differentiation of bone marrow stromal cells in vitro.

Authors: Ying Zhang; Xiaopei Deng; Erica L Scheller; Tae-Geon Kwon; Joerg Lahann; Renny T Franceschi; Paul H Krebsbach
Journal: Biomaterials Date: 2010-02-02 Impact factor: 12.479

6. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.

Authors: Z Lin; J V Sugai; Q Jin; L A Chandler; W V Giannobile
Journal: J Periodontal Res Date: 2008-08 Impact factor: 4.419

7. Injectable chitosan microparticles incorporating bone morphogenetic protein-7 for bone tissue regeneration.

Authors: Venkata P Mantripragada; Ambalangodage C Jayasuriya
Journal: J Biomed Mater Res A Date: 2014-02-14 Impact factor: 4.396

8. Conformal encapsulation of three-dimensional, bioresorbable polymeric scaffolds using plasma-enhanced chemical vapor deposition.

Authors: Morgan J Hawker; Adoracion Pegalajar-Jurado; Ellen R Fisher
Journal: Langmuir Date: 2014-10-07 Impact factor: 3.882

9. The synergetic bone-forming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds.

Authors: Yufeng Zhang; Bin Shi; Chengzhang Li; Yining Wang; Yun Chen; Wei Zhang; Tao Luo; Xiangrong Cheng
Journal: J Control Release Date: 2009-02-27 Impact factor: 9.776

Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.

1. Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo.

2. Cellular transduction gradients via vapor-deposited polymer coatings.

3. Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use.

4. In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease.

5. The effects of Runx2 immobilization on poly (epsilon-caprolactone) on osteoblast differentiation of bone marrow stromal cells in vitro.

6. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.

7. Injectable chitosan microparticles incorporating bone morphogenetic protein-7 for bone tissue regeneration.

8. Conformal encapsulation of three-dimensional, bioresorbable polymeric scaffolds using plasma-enhanced chemical vapor deposition.

9. The synergetic bone-forming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds.

10. PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration.

Review 1. Personalized scaffolding technologies for alveolar bone regenerative medicine.

2. Current and future trends in periodontal tissue engineering and bone regeneration.

3. Micropatterned Scaffolds with Immobilized Growth Factor Genes Regenerate Bone and Periodontal Ligament-Like Tissues.

Review 4. CVD Polymers for Devices and Device Fabrication.

Review 5. Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects.

Review 6. Growth factor loading on aliphatic polyester scaffolds.