Saleha Sajid1, William Dale2, Karen Mustian3, Ashwin Kotwal4, Charles Heckler5, Michelle Porto5, Chunkit Fung6, Supriya G Mohile7. 1. Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: salehasajid@gmail.com. 2. Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: wdale@medicine.bsd.uchicago.edu. 3. Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: Karen_mustian@urmc.rochester.edu. 4. Department of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: akotwal@uchicago.edu. 5. Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. 6. Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: chunkit_fung@urmc.rochester.edu. 7. Department of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: Supriya_mohile@urmc.rochester.edu.
Abstract
BACKGROUND:Androgen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC). METHODS: We conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care armin men ≥70 years with PC receiving ADT. The intervention lasted for 6 weeks, with follow-up at 12 weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score. Mixed effects regression models were used to assess change in outcomes over time. RESULTS:Mean participant age was 70 years (range: 67-93). Eight patients were randomized to the Wii-Fit arm, 6 to the EXCAP arm, and 5 to the usual-care arm. SPPB scores remained nearly constant in the usual-care arm (β=-0.12; p=0.79), while individuals in the EXCAP arm had on average a 1.2 point increase at each follow-up (β=1.20; 95% CI: 0.36, 2.06). The Wii-fit arm had a non-significant increase in SPPB score over time relative to usual-care (β=0.32; 95% CI -0.43, 1.06; p=0.46). Individuals in the EXCAP arm had an increase in steps per day over time compared to the usual-care arm (p-value=0.006); the EXCAP arm had an increase of 2720 steps (95% CI: 1313, 4128) while the usual-care arm had an increase of 97 steps (95% CI: -1140, 1333). Participants in the Wii-Fit arm had an increase of 1020 steps (95% CI: -474, 1238, p=0.710). Other outcomes (i.e., handgrip strength, lean muscle mass, and chest press repetitions) were not statistically significant. CONCLUSIONS: A home-based aerobic and resistance exercise program, EXCAP, shows promise for improving PP in older men with PC on ADT.
RCT Entities:
BACKGROUND: Androgen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC). METHODS: We conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care arm in men ≥70 years with PC receiving ADT. The intervention lasted for 6 weeks, with follow-up at 12 weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score. Mixed effects regression models were used to assess change in outcomes over time. RESULTS: Mean participant age was 70 years (range: 67-93). Eight patients were randomized to the Wii-Fit arm, 6 to the EXCAP arm, and 5 to the usual-care arm. SPPB scores remained nearly constant in the usual-care arm (β=-0.12; p=0.79), while individuals in the EXCAP arm had on average a 1.2 point increase at each follow-up (β=1.20; 95% CI: 0.36, 2.06). The Wii-fit arm had a non-significant increase in SPPB score over time relative to usual-care (β=0.32; 95% CI -0.43, 1.06; p=0.46). Individuals in the EXCAP arm had an increase in steps per day over time compared to the usual-care arm (p-value=0.006); the EXCAP arm had an increase of 2720 steps (95% CI: 1313, 4128) while the usual-care arm had an increase of 97 steps (95% CI: -1140, 1333). Participants in the Wii-Fit arm had an increase of 1020 steps (95% CI: -474, 1238, p=0.710). Other outcomes (i.e., handgrip strength, lean muscle mass, and chest press repetitions) were not statistically significant. CONCLUSIONS: A home-based aerobic and resistance exercise program, EXCAP, shows promise for improving PP in older men with PC on ADT.
Authors: Lisa K Sprod; Supriya G Mohile; Wendy Demark-Wahnefried; Michelle C Janelsins; Luke J Peppone; Gary R Morrow; Raymond Lord; Howard Gross; Karen M Mustian Journal: J Geriatr Oncol Date: 2012-01-27 Impact factor: 3.599
Authors: Alessandra Pluchino; Sae Yong Lee; Shihab Asfour; Bernard A Roos; Joseph F Signorile Journal: Arch Phys Med Rehabil Date: 2012-03-11 Impact factor: 3.966
Authors: Victoria Mock; Constantine Frangakis; Nancy E Davidson; Mary E Ropka; Mary Pickett; Barbara Poniatowski; Kerry J Stewart; Lane Cameron; Kristin Zawacki; Laura J Podewils; Gary Cohen; Ruth McCorkle Journal: Psychooncology Date: 2005-06 Impact factor: 3.894
Authors: Kathryn Bylow; William Dale; Karen Mustian; Walter M Stadler; Miriam Rodin; William Hall; Mark Lachs; Supriya G Mohile Journal: Urology Date: 2008-06-17 Impact factor: 2.649
Authors: Kah Poh Loh; Ian R Kleckner; Po-Ju Lin; Supriya G Mohile; Beverly E Canin; Marie A Flannery; Chunkit Fung; Richard F Dunne; Javier Bautista; Eva Culakova; Amber S Kleckner; Luke J Peppone; Michelle Janelsins; Colin McHugh; Alison Conlin; Jonathan K Cho; Sameer Kasbari; Benjamin T Esparaz; J Philip Kuebler; Karen M Mustian Journal: J Am Geriatr Soc Date: 2019-05 Impact factor: 5.562
Authors: Ronald Maggiore; Zachary S Zumsteg; Karlynn BrintzenhofeSzoc; Kelly M Trevino; Ajeet Gajra; Beatriz Korc-Grodzicki; Joel B Epstein; Stewart M Bond; Ira Parker; Julie A Kish; Barbara A Murphy; Noam A VanderWalde Journal: Int J Radiat Oncol Biol Phys Date: 2017-07-15 Impact factor: 7.038
Authors: Kah Poh Loh; Chandrika Sanapala; Grace Di Giovanni; Heidi D Klepin; Michelle Janelsins; Rebecca Schnall; Eva Culakova; Paula Vertino; Martha Susiarjo; Jason H Mendler; Jane L Liesveld; Po-Ju Lin; Richard F Dunne; Ian Kleckner; Karen Mustian; Supriya G Mohile Journal: J Geriatr Oncol Date: 2021-03-04 Impact factor: 3.929
Authors: Kah Poh Loh; Chandrika Sanapala; Michelle Janelsins; Heidi D Klepin; Rebecca Schnall; Eva Culakova; Michael B Sohn; Paula Vertino; Martha Susiarjo; Marielle Jensen-Battaglia; Michael W Becker; Jane Liesveld; Jason H Mendler; Eric Huselton; Po-Ju Lin; Karen Mustian Journal: J Geriatr Oncol Date: 2021-12-21 Impact factor: 3.929
Authors: Rebecca R Turner; Liz Steed; Helen Quirk; Rosa U Greasley; John M Saxton; Stephanie Jc Taylor; Derek J Rosario; Mohamed A Thaha; Liam Bourke Journal: Cochrane Database Syst Rev Date: 2018-09-19