Oriana Monraisin1, Lucie Chansel-Debordeaux2, Alexandra Chiron3, Sébastien Floret4, Steven Cens5, Sylvain Bourrinet6, Sophie Paulhac7, Clément Jimenez2, Jean Parinaud8, Roger Leandri9. 1. Médecine de la Reproduction, CHU Toulouse, Toulouse, France. 2. Biologie de la Reproduction-CECOS Groupe Hospitalier Pellegrin-Maternité, Bordeaux, France. 3. Centre d'Assistance Médicale à la Procréation Bordeaux Aquitaine Santé, Polyclinique Jean Villar, Bruges, France. 4. Clinique Francheville, Perigueux, France. 5. Polyclinique de Navarre, Pau, France. 6. Centre Fivete Côte Basque, Bayonne, France. 7. Centre d'AMP, Hôpital Mère et Enfant, Limoges, France. 8. Médecine de la Reproduction, CHU Toulouse, Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, Toulouse, France. Electronic address: parinaud.j@chu-toulouse.fr. 9. Médecine de la Reproduction, CHU Toulouse, Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, Toulouse, France.
Abstract
OBJECTIVE: To determine the best practices of intrauterine insemination with the partner's fresh sperm. DESIGN: Prospective multicenter observational study. SETTING: Assisted reproduction technology (ART) centers. PATIENT(S): Seven hundred and seven patients entering the program, regardless of age or cause of infertility. INTERVENTION(S): Intrauterine insemination by standard procedures. MAIN OUTCOME MEASURE(S): Effect of patient characteristics (duration of infertility, indications, age, parity, body mass index, semen parameters) as well as IUI parameters on delivery rates per couple or per attempt. RESULT(S): The overall live birth rate was 11.4% per cycle, varying from 8.4% to 17.6% between centers. The main differences in practice that had a statistically significant impact on the delivery rate were the use of gonadotropin-releasing hormone (GnRH) antagonists (15.2% with versus 9.4% without) and the number of mature recruited follicles (9.4% for one versus 15.2% for two). CONCLUSION(S): Our results indicate that the use of GnRH antagonists has a positive effect on the delivery rate, especially in the multifollicular stimulations that are required when women are older than 27 years.
OBJECTIVE: To determine the best practices of intrauterine insemination with the partner's fresh sperm. DESIGN: Prospective multicenter observational study. SETTING: Assisted reproduction technology (ART) centers. PATIENT(S): Seven hundred and seven patients entering the program, regardless of age or cause of infertility. INTERVENTION(S): Intrauterine insemination by standard procedures. MAIN OUTCOME MEASURE(S): Effect of patient characteristics (duration of infertility, indications, age, parity, body mass index, semen parameters) as well as IUI parameters on delivery rates per couple or per attempt. RESULT(S): The overall live birth rate was 11.4% per cycle, varying from 8.4% to 17.6% between centers. The main differences in practice that had a statistically significant impact on the delivery rate were the use of gonadotropin-releasing hormone (GnRH) antagonists (15.2% with versus 9.4% without) and the number of mature recruited follicles (9.4% for one versus 15.2% for two). CONCLUSION(S): Our results indicate that the use of GnRH antagonists has a positive effect on the delivery rate, especially in the multifollicular stimulations that are required when women are older than 27 years.
Authors: LaTasha B Craig; Sushila Arya; Heather R Burks; Kaitlin Warta; Christen Jarshaw; Karl R Hansen; Jennifer D Peck Journal: Fertil Steril Date: 2021-08-18 Impact factor: 7.329