Courtney M Rowan1, Shira J Gertz, Jennifer McArthur, Julie C Fitzgerald, Mara E Nitu, Ashley Loomis, Deyin D Hsing, Christine N Duncan, Kris M Mahadeo, Lincoln S Smith, Jerelyn Moffet, Mark W Hall, Emily L Pinos, Ira M Cheifetz, Robert F Tamburro. 1. 1Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. 2Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ. 3Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI. 4Department of Anesthesia, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. 6Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY. 7Department of Pediatrics, Dana-Farber Cancer Institute, Boston, MA. 8Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY. 9Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA. 10Department of Pediatrics, Duke Children's Hospital, Durham, NC. 11Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH. 12Department of Pediatrics, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA. 13Department of Public Health, Pennsylvania State University College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA.
Abstract
OBJECTIVE: To establish the current respiratory practice patterns in pediatric hematopoietic stem cell transplant patients and investigate their associations with mortality across multiple centers. DESIGN: Retrospective cohort between 2009 and 2014. SETTING: Twelve children's hospitals in the United States. PATIENTS: Two hundred twenty-two pediatric allogeneic hematopoietic stem cell transplant recipients with acute respiratory failure using invasive mechanical ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: PICU mortality of our cohort was 60.4%. Mortality at 180 days post PICU discharge was 74%. Length of PICU stay prior to initiation of invasive mechanical ventilation was significantly lower in survivors, and the odds of mortality increased for longer length of PICU stay prior to intubation. A total of 91 patients (41%) received noninvasive ventilation at some point during their PICU stay prior to intubation. Noninvasive ventilation use preintubation was associated with increased mortality (odds ratio, 2.1; 95% CI, 1.2-3.6; p = 0.010). Patients ventilated longer than 15 days had higher odds of death (odds ratio, 2.4; 95% CI, 1.3-4.2; p = 0.004). Almost 40% of patients (n = 85) were placed on high-frequency oscillatory ventilation with a mortality of 76.5% (odds ratio, 3.3; 95% CI, 1.7-6.5; p = 0.0004). Of the 20 patients who survived high-frequency oscillatory ventilation, 18 were placed on high-frequency oscillatory ventilation no later than the third day of invasive mechanical ventilation. In this subset of 85 patients, transition to high-frequency oscillatory ventilation within 2 days of the start of invasive mechanical ventilation resulted in a 76% decrease in the odds of death compared with those who transitioned to high-frequency oscillatory ventilation later in the invasive mechanical ventilation course. CONCLUSIONS: This study suggests that perhaps earlier more aggressive critical care interventions in the pediatric hematopoietic stem cell transplant patient with respiratory failure requiring invasive mechanical ventilation may offer an opportunity to improve outcomes.
OBJECTIVE: To establish the current respiratory practice patterns in pediatric hematopoietic stem cell transplant patients and investigate their associations with mortality across multiple centers. DESIGN: Retrospective cohort between 2009 and 2014. SETTING: Twelve children's hospitals in the United States. PATIENTS: Two hundred twenty-two pediatric allogeneic hematopoietic stem cell transplant recipients with acute respiratory failure using invasive mechanical ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: PICU mortality of our cohort was 60.4%. Mortality at 180 days post PICU discharge was 74%. Length of PICU stay prior to initiation of invasive mechanical ventilation was significantly lower in survivors, and the odds of mortality increased for longer length of PICU stay prior to intubation. A total of 91 patients (41%) received noninvasive ventilation at some point during their PICU stay prior to intubation. Noninvasive ventilation use preintubation was associated with increased mortality (odds ratio, 2.1; 95% CI, 1.2-3.6; p = 0.010). Patients ventilated longer than 15 days had higher odds of death (odds ratio, 2.4; 95% CI, 1.3-4.2; p = 0.004). Almost 40% of patients (n = 85) were placed on high-frequency oscillatory ventilation with a mortality of 76.5% (odds ratio, 3.3; 95% CI, 1.7-6.5; p = 0.0004). Of the 20 patients who survived high-frequency oscillatory ventilation, 18 were placed on high-frequency oscillatory ventilation no later than the third day of invasive mechanical ventilation. In this subset of 85 patients, transition to high-frequency oscillatory ventilation within 2 days of the start of invasive mechanical ventilation resulted in a 76% decrease in the odds of death compared with those who transitioned to high-frequency oscillatory ventilation later in the invasive mechanical ventilation course. CONCLUSIONS: This study suggests that perhaps earlier more aggressive critical care interventions in the pediatric hematopoietic stem cell transplant patient with respiratory failure requiring invasive mechanical ventilation may offer an opportunity to improve outcomes.
Authors: Courtney M Rowan; Ashley Loomis; Jennifer McArthur; Lincoln S Smith; Shira J Gertz; Julie C Fitzgerald; Mara E Nitu; Elizabeth As Moser; Deyin D Hsing; Christine N Duncan; Kris M Mahadeo; Jerelyn Moffet; Mark W Hall; Emily L Pinos; Robert F Tamburro; Ira M Cheifetz Journal: Respir Care Date: 2017-12-26 Impact factor: 2.258
Authors: Robert B Lindell; Shira J Gertz; Courtney M Rowan; Jennifer McArthur; Florian Beske; Adrian Plunkett; Scott L Weiss; Neal J Thomas; Vinay M Nadkarni; Julie C Fitzgerald Journal: Pediatr Crit Care Med Date: 2017-12 Impact factor: 3.624
Authors: Cara E Morin; Morgan P McBee; Lama Elbahlawan; Lindsay M Griffin; Gabriela M Maron; HaiThuy N Nguyen; Akshay Sharma; Elizabeth J Snyder; Jean Jeudy Journal: Pediatr Radiol Date: 2022-07-02
Authors: Matteo Di Nardo; Ali H Ahmad; Pietro Merli; Matthew S Zinter; Leslie E Lehman; Courtney M Rowan; Marie E Steiner; Sangeeta Hingorani; Joseph R Angelo; Hisham Abdel-Azim; Sajad J Khazal; Basirat Shoberu; Jennifer McArthur; Rajinder Bajwa; Saad Ghafoor; Samir H Shah; Hitesh Sandhu; Karen Moody; Brandon D Brown; Maria E Mireles; Diana Steppan; Taylor Olson; Lakshmi Raman; Brian Bridges; Christine N Duncan; Sung Won Choi; Rita Swinford; Matt Paden; James D Fortenberry; Giles Peek; Pierre Tissieres; Daniele De Luca; Franco Locatelli; Selim Corbacioglu; Martin Kneyber; Alessio Franceschini; Simon Nadel; Matthias Kumpf; Alessandra Loreti; Roelie Wösten-Van Asperen; Orsola Gawronski; Joe Brierley; Graeme MacLaren; Kris M Mahadeo Journal: Lancet Child Adolesc Health Date: 2021-12-09
Authors: Alicia M Teagarden; Jodi L Skiles; Andrew L Beardsley; Michael J Hobson; Elizabeth A S Moser; Jamie L Renbarger; Courtney M Rowan Journal: Pediatr Transplant Date: 2017-07-02
Authors: Robert F Tamburro; Kenneth R Cooke; Stella M Davies; Samuel Goldfarb; James S Hagood; Ashok Srinivasan; Marie E Steiner; Dennis Stokes; Nancy DiFronzo; Nahed El-Kassar; Nonniekaye Shelburne; Aruna Natarajan Journal: Ann Am Thorac Soc Date: 2021-03
Authors: Courtney M Rowan; Julie C Fitzgerald; Asya Agulnik; Matt S Zinter; Matthew P Sharron; James E Slaven; Erin M Kreml; Rajinder P S Bajwa; Kris M Mahadeo; Jerelyn Moffet; Keiko M Tarquinio; Marie E Steiner Journal: Front Oncol Date: 2021-05-27 Impact factor: 6.244