Literature DB >> 26910078

Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors.

Hong S Kim1, Alexander T Pearson2,3, Jacques E Nör4,5,6,7.   

Abstract

Drug resistance remains a significant problem in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Recent reports showed that a subpopulation of highly tumorigenic cells, called cancer stem cells (CSCs), is uniquely resistant to chemotherapy, suggesting that these cells play an important role in the relapse of HNSCC. The development of methods for the isolation and culture of cancer stem cells is a key step to enable studies exploring the mechanisms underlying the role of these cells in chemoresistance. Here, we describe a method to isolate cancer stem cells from primary head and neck tumors and for the generation of orospheres.

Entities:  

Keywords:  Cancer stem cells; Chemoresistance; Head and neck squamous cell carcinoma; Multipotency; Orospheres; Self-renewal

Mesh：

Year:  2016        PMID： 26910078      PMCID： PMC5344035          DOI： 10.1007/978-1-4939-3347-1_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  13 in total

1.  Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

Authors:  B A Reynolds; S Weiss
Journal:  Science       Date:  1992-03-27       Impact factor: 47.728

2.  Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells.

Authors:  Sudha Krishnamurthy; Zhihong Dong; Dmitry Vodopyanov; Atsushi Imai; Joseph I Helman; Mark E Prince; Max S Wicha; Jacques E Nör
Journal:  Cancer Res       Date:  2010-11-23       Impact factor: 12.701

3.  A subpopulation of CD133(+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy.

Authors:  Qunzhou Zhang; Shihong Shi; Yun Yen; Jimmy Brown; Joseph Quoc Ta; Anh D Le
Journal:  Cancer Lett       Date:  2009-09-11       Impact factor: 8.679

Review 4.  Head and neck cancers.

Authors:  David G Pfister; Kie-Kian Ang; David M Brizel; Barbara A Burtness; Anthony J Cmelak; A Dimitrios Colevas; Frank Dunphy; David W Eisele; Jill Gilbert; Maura L Gillison; Robert I Haddad; Bruce H Haughey; Wesley L Hicks; Ying J Hitchcock; Merrill S Kies; William M Lydiatt; Ellie Maghami; Renato Martins; Thomas McCaffrey; Bharat B Mittal; Harlan A Pinto; John A Ridge; Sandeep Samant; Giuseppe Sanguineti; David E Schuller; Jatin P Shah; Sharon Spencer; Andy Trotti; Randal S Weber; Gregory T Wolf; Frank Worden
Journal:  J Natl Compr Canc Netw       Date:  2011-06-01       Impact factor: 11.908

5.  Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world.

Authors:  Farin Kamangar; Graça M Dores; William F Anderson
Journal:  J Clin Oncol       Date:  2006-05-10       Impact factor: 44.544

6.  Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma.

Authors:  M E Prince; R Sivanandan; A Kaczorowski; G T Wolf; M J Kaplan; P Dalerba; I L Weissman; M F Clarke; L E Ailles
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-08       Impact factor: 11.205

7.  Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase.

Authors:  Matthew R Clay; Mark Tabor; John Henry Owen; Thomas E Carey; Carol R Bradford; Gregory T Wolf; Max S Wicha; Mark E Prince
Journal:  Head Neck       Date:  2010-09       Impact factor: 3.147

8.  Cisplatin induces Bmi-1 and enhances the stem cell fraction in head and neck cancer.

Authors:  Carolina Nör; Zhaocheng Zhang; Kristy A Warner; Lisiane Bernardi; Fernanda Visioli; Joseph I Helman; Rafael Roesler; Jacques E Nör
Journal:  Neoplasia       Date:  2014-02       Impact factor: 5.715

9.  Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck.

Authors:  Atsushi Okamoto; Kazuaki Chikamatsu; Koichi Sakakura; Kyosuke Hatsushika; Goro Takahashi; Keisuke Masuyama
Journal:  Oral Oncol       Date:  2008-11-21       Impact factor: 5.337

10.  Orosphere assay: a method for propagation of head and neck cancer stem cells.

Authors:  Sudha Krishnamurthy; Jacques E Nör
Journal:  Head Neck       Date:  2012-07-13       Impact factor: 3.147
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  2 in total

Review 1.  Radiotherapy targeting cancer stem cells "awakens" them to induce tumour relapse and metastasis in oral cancer.

Authors:  Yangfan Liu; Miao Yang; Jingjing Luo; Hongmei Zhou
Journal:  Int J Oral Sci       Date:  2020-06-24       Impact factor: 6.344

Review 2.  Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications.

Authors:  Claudia Peitzsch; Jacqueline Nathansen; Sebastian I Schniewind; Franziska Schwarz; Anna Dubrovska
Journal:  Cancers (Basel)       Date:  2019-05-02       Impact factor: 6.639
  2 in total

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