AIM: To develop Finasteride-loaded self micro-emulsifying drug delivery systems (SMEDDS) for the treatment of hormonal associated problems. MATERIALS & METHODS: Ternary phase diagrams were constructed to obtain self-emulsification regions. Multivariate statistical methods viz. Principal component analysis and agglomerative hierarchy clustering analysis were used to evaluate the microemulsions stability. In vitro redispersibility study was adopted and two formulations were selected for spray-drying. Further investigations were performed (Fourier transform infrared, x-ray diffraction and transmission electron microscopy). Finally, the in vivo performance was tested in human volunteers. RESULTS: Multivariate statistical methods selected stable SMEDDS. Spray-drying utilizing maltodextrin/leucin carrier system yielded a flowable product. Selected solid SMEDDS scored 129.35% relative bioavailability compared with a commercial tablet. CONCLUSION: The developed SMEDDS poses successful platform for glucosteroid analogs oral delivery.
AIM: To develop Finasteride-loaded self micro-emulsifying drug delivery systems (SMEDDS) for the treatment of hormonal associated problems. MATERIALS & METHODS: Ternary phase diagrams were constructed to obtain self-emulsification regions. Multivariate statistical methods viz. Principal component analysis and agglomerative hierarchy clustering analysis were used to evaluate the microemulsions stability. In vitro redispersibility study was adopted and two formulations were selected for spray-drying. Further investigations were performed (Fourier transform infrared, x-ray diffraction and transmission electron microscopy). Finally, the in vivo performance was tested in human volunteers. RESULTS: Multivariate statistical methods selected stable SMEDDS. Spray-drying utilizing maltodextrin/leucin carrier system yielded a flowable product. Selected solid SMEDDS scored 129.35% relative bioavailability compared with a commercial tablet. CONCLUSION: The developed SMEDDS poses successful platform for glucosteroid analogs oral delivery.
Authors: Zhenbao Li; Wenjuan Zhang; Yan Gao; Rongwu Xiang; Yan Liu; Mingming Hu; Mei Zhou; Xiaohong Liu; Yongjun Wang; Zhonggui He; Yinghua Sun; Jin Sun Journal: Drug Deliv Transl Res Date: 2017-02 Impact factor: 4.617
Authors: Aousaf Ahmad; Mahmood Ahmad; Muhammad Usman Minhas; Muhammad Sarfraz; Muhammad Sohail; Kifayat Ullah Khan; Sana Tanveer; Shakeel Ijaz Journal: Biomed Res Int Date: 2022-07-19 Impact factor: 3.246
Authors: Malik Muhammad Irfan; Shefaat Ullah Shah; Ikram Ullah Khan; Muhammad Usman Munir; Nauman Rahim Khan; Kifayat Ullah Shah; Saif Ur Rehman; Muhammad Sohaib; Hafiz Muhammad Basit; Saima Mahmood Journal: Int J Nanomedicine Date: 2021-02-16