Literature DB >> 26907822

New-onset haematoproteinuria in a 63-year-old man with intraperitoneal lymph node enlargement.

Akihiro Minakawa1, Shuichi Hisanaga2, Yuji Sato3, Shouichi Fujimoto4.   

Abstract

A 63-year-old man was referred to our hospital because of renal dysfunction with haematoproteinuria. Intraperitoneal lymph node enlargement was also noted. M protein was not detected by electrophoresis of his serum and urine; however, an increase in the κ/λ ratio was detected by free light-chain assay. Percutaneous kidney biopsy was performed, and the patient was diagnosed with proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Lymph node biopsy showed follicular lymphoma. Urinalysis findings improved after treatment of the lymphoma. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits is rarely considered to be associated with haematological disease. We report a case of lymphoma-associated proliferative glomerulonephritis with monoclonal immunoglobulin deposits with light-chain abnormality detected by free light-chain assay, but not by electrophoresis. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 26907822      PMCID: PMC4769458          DOI: 10.1136/bcr-2016-214366

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

1.  Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.

Authors:  Sean J Barbour; Monica C Beaulieu; Nadia Y Zalunardo; Alex B Magil
Journal:  Nephrol Dial Transplant       Date:  2011-06-01       Impact factor: 5.992

2.  Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine.

Authors:  A R Bradwell; H D Carr-Smith; G P Mead; L X Tang; P J Showell; M T Drayson; R Drew
Journal:  Clin Chem       Date:  2001-04       Impact factor: 8.327

3.  Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-kappa paraprotein.

Authors:  David J Evans; Momir Macanovic; Michael J Dunn; Charles D Pusey
Journal:  Nephron Clin Pract       Date:  2003

Review 4.  Diagnosis of monoclonal gammopathy of renal significance.

Authors:  Frank Bridoux; Nelson Leung; Colin A Hutchison; Guy Touchard; Sanjeev Sethi; Jean-Paul Fermand; Maria M Picken; Guillermo A Herrera; Efstathios Kastritis; Giampaolo Merlini; Murielle Roussel; Fernando C Fervenza; Angela Dispenzieri; Robert A Kyle; Samih H Nasr
Journal:  Kidney Int       Date:  2015-01-21       Impact factor: 10.612

Review 5.  Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.

Authors:  Nelson Leung; Frank Bridoux; Colin A Hutchison; Samih H Nasr; Paul Cockwell; Jean-Paul Fermand; Angela Dispenzieri; Kevin W Song; Robert A Kyle
Journal:  Blood       Date:  2012-10-09       Impact factor: 22.113

6.  Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis.

Authors:  Samih H Nasr; Glen S Markowitz; M Barry Stokes; Surya V Seshan; Elsa Valderrama; Gerald B Appel; Pierre Aucouturier; Vivette D D'Agati
Journal:  Kidney Int       Date:  2004-01       Impact factor: 10.612

Review 7.  How I treat monoclonal gammopathy of renal significance (MGRS).

Authors:  Jean-Paul Fermand; Frank Bridoux; Robert A Kyle; Efstathios Kastritis; Brendan M Weiss; Mark A Cook; Mark T Drayson; Angela Dispenzieri; Nelson Leung
Journal:  Blood       Date:  2013-10-09       Impact factor: 22.113

8.  Proliferative glomerulonephritis with monoclonal IgG deposits.

Authors:  Samih H Nasr; Anjali Satoskar; Glen S Markowitz; Anthony M Valeri; Gerald B Appel; Michael B Stokes; Tibor Nadasdy; Vivette D D'Agati
Journal:  J Am Soc Nephrol       Date:  2009-05-21       Impact factor: 10.121

9.  Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease.

Authors:  Colin A Hutchison; Stephen Harding; Pete Hewins; Graham P Mead; John Townsend; Arthur R Bradwell; Paul Cockwell
Journal:  Clin J Am Soc Nephrol       Date:  2008-11       Impact factor: 8.237

Review 10.  Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: a comprehensive review.

Authors:  Khalil M Charafeddine; Mark N Jabbour; Raneem H Kadi; Rose T Daher
Journal:  Am J Clin Pathol       Date:  2012-06       Impact factor: 2.493

  10 in total

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