Chintan Pandya1, Allison Magnuson2, William Dale3, Lisa Lowenstein2, Chunkit Fung2, Supriya G Mohile4. 1. Division of Health Policy and Outcomes Research, Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA. 2. Division of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA. 3. Division of Geriatrics and Palliative Care, University of Chicago, Chicago, IL, USA. 4. Division of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: supriya_mohile@urmc.rochester.edu.
Abstract
OBJECTIVE: To examine the association between falls and health-related quality of life (HRQOL) in older cancer survivors. MATERIALS AND METHODS: Using the 2006-2011 Surveillance, Epidemiology, and End Results cancer registry system and the Medicare Health Outcomes Survey (SEER-MHOS) linkage database, a cross-sectional analysis was performed including 17,958 older cancer survivors. Multivariable regression models were used to evaluate the association of falls with HRQOL measured by the physical component summary (PCS) and mental component summary (MCS) scores on the Veteran RAND 12-item health survey after controlling for demographic, health- and cancer-related factors. A longitudinal analysis using the analysis of covariance (ANCOVA) models was also conducted comparing changes in HRQOL of older cancer survivors who fell with HRQOL of older patients with cancer who did not fall. RESULTS: In the cross-sectional analysis, 4524 (25%) cancer survivors who fell reported a significantly lower PCS (-2.18; SE=0.16) and MCS (2.00; SE=0.17) scores compared to those who did not (N=13,434). In the longitudinal analysis, after adjusting for baseline HRQOL scores and covariates, patients who fell reported a decline in mean HRQOL scores of both PCS (-1.54; SE=0.26) and MCS (-1.71; SE=0.27). Presence of depression, functional impairment and comorbidities was significantly associated with lower HRQOL scores. CONCLUSION: Falls are associated with lower HRQOL scores and are associated with a significant prospective decline in HRQOL in older cancer survivors. Further research is necessary to determine if assessment and intervention programs can help improve HRQOL by reducing the likelihood of falls.
OBJECTIVE: To examine the association between falls and health-related quality of life (HRQOL) in older cancer survivors. MATERIALS AND METHODS: Using the 2006-2011 Surveillance, Epidemiology, and End Results cancer registry system and the Medicare Health Outcomes Survey (SEER-MHOS) linkage database, a cross-sectional analysis was performed including 17,958 older cancer survivors. Multivariable regression models were used to evaluate the association of falls with HRQOL measured by the physical component summary (PCS) and mental component summary (MCS) scores on the Veteran RAND 12-item health survey after controlling for demographic, health- and cancer-related factors. A longitudinal analysis using the analysis of covariance (ANCOVA) models was also conducted comparing changes in HRQOL of older cancer survivors who fell with HRQOL of older patients with cancer who did not fall. RESULTS: In the cross-sectional analysis, 4524 (25%) cancer survivors who fell reported a significantly lower PCS (-2.18; SE=0.16) and MCS (2.00; SE=0.17) scores compared to those who did not (N=13,434). In the longitudinal analysis, after adjusting for baseline HRQOL scores and covariates, patients who fell reported a decline in mean HRQOL scores of both PCS (-1.54; SE=0.26) and MCS (-1.71; SE=0.27). Presence of depression, functional impairment and comorbidities was significantly associated with lower HRQOL scores. CONCLUSION: Falls are associated with lower HRQOL scores and are associated with a significant prospective decline in HRQOL in older cancer survivors. Further research is necessary to determine if assessment and intervention programs can help improve HRQOL by reducing the likelihood of falls.
Authors: Erin E Kent; Anita Ambs; Sandra A Mitchell; Steven B Clauser; Ashley Wilder Smith; Ron D Hays Journal: Cancer Date: 2014-11-04 Impact factor: 6.860
Authors: Arti Hurria; Kayo Togawa; Supriya G Mohile; Cynthia Owusu; Heidi D Klepin; Cary P Gross; Stuart M Lichtman; Ajeet Gajra; Smita Bhatia; Vani Katheria; Shira Klapper; Kurt Hansen; Rupal Ramani; Mark Lachs; F Lennie Wong; William P Tew Journal: J Clin Oncol Date: 2011-08-01 Impact factor: 44.544
Authors: Carey E Gleason; Ronald E Gangnon; Barbara L Fischer; Jane E Mahoney Journal: Dement Geriatr Cogn Disord Date: 2009-07-11 Impact factor: 2.959
Authors: Bryce B Reeve; Arnold L Potosky; Ashley Wilder Smith; Paul K Han; Ron D Hays; William W Davis; Neeraj K Arora; Samuel C Haffer; Steven B Clauser Journal: J Natl Cancer Inst Date: 2009-06-09 Impact factor: 13.506
Authors: Andrew M Blakely; Dayana Chanson; F Lennie Wong; Oliver S Eng; Stephen M Sentovich; Kurt A Melstrom; Lily L Lai; Yuman Fong; Virginia Sun Journal: Support Care Cancer Date: 2019-11-15 Impact factor: 3.603
Authors: Shirit Kamil-Rosenberg; Peter Kokkinos; Christina Grune de Souza E Silva; Win Leth Shwe Yee; Joshua Abella; Khin Chan; Jonathan Myers Journal: Int J Cardiol Heart Vasc Date: 2020-10-27
Authors: Joanna Sulicka; Agnieszka Pac; Monika Puzianowska-Kuźnicka; Tomasz Zdrojewski; Jerzy Chudek; Beata Tobiasz-Adamczyk; Małgorzata Mossakowska; Anna Skalska; Andrzej Więcek; Tomasz Grodzicki Journal: J Cancer Surviv Date: 2018-01-09 Impact factor: 4.442
Authors: T M Wildes; S Alibhai; S Sattar; K Haase; S Kuster; M Puts; S Spoelstra; C Bradley Journal: Support Care Cancer Date: 2020-07-16 Impact factor: 3.603