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Literature DB >> 26907466

Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.

Jeffrey E López¹, Eric D Sullivan¹, Carol A Fierke^1,2.

Abstract

Epigenetic regulation is a key factor in cellular homeostasis. Post-translational modifications (PTMs) are a central focus of this regulation as they function as signaling markers within the cell. Lysine acetylation is a dynamic, reversible PTM that has garnered recent attention due to alterations in various types of cancer. Acetylation levels are regulated by two opposing enzyme families: lysine acetyltransferases (KATs) and histone deacetylases (HDACs). HDACs are key players in epigenetic regulation and have a role in the silencing of tumor suppressor genes. The dynamic equilibrium of acetylation makes HDACs attractive targets for drug therapy. However, substrate selectivity and biological function of HDAC isozymes is poorly understood. This review outlines the current understanding of the roles and specific epigenetic interactions of the metal-dependent HDACs in addition to their roles in cancer.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2016 PMID： 26907466 PMCID： PMC5590829 DOI： 10.1021/acschembio.5b01067

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

107 in total

Review 1. Regulatory signal transduction pathways for class IIa histone deacetylases.

Authors: Maribel Parra; Eric Verdin
Journal: Curr Opin Pharmacol Date: 2010-05-04 Impact factor: 5.547

2. Injury-induced HDAC5 nuclear export is essential for axon regeneration.

Authors: Yongcheol Cho; Roman Sloutsky; Kristen M Naegle; Valeria Cavalli
Journal: Cell Date: 2013-11-07 Impact factor: 41.582

Review 3. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond.

Authors: Eric Verdin; Melanie Ott
Journal: Nat Rev Mol Cell Biol Date: 2014-12-30 Impact factor: 94.444

Review 4. Oncolytic viruses and their application to cancer immunotherapy.

Authors: E Antonio Chiocca; Samuel D Rabkin
Journal: Cancer Immunol Res Date: 2014-04 Impact factor: 11.151

5. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

Authors: Makoto Taniguchi; Maria B Carreira; Laura N Smith; Benjamin C Zirlin; Rachael L Neve; Christopher W Cowan
Journal: Neuron Date: 2012-01-12 Impact factor: 17.173

6. Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.

Authors: Jenny Y Sun; Lian Xu; Hsuyi Tseng; Bryan Ciccarelli; Mariateresa Fulciniti; Zachary R Hunter; Kaveh Maghsoudi; Evdoxia Hatjiharissi; Yangsheng Zhou; Guang Yang; Biao Zhu; Xia Liu; P Gong; Leukothea Ioakimidis; Patricia Sheehy; Christopher J Patterson; Nikhil C Munshi; Owen A O'Connor; Steven P Treon
Journal: Clin Lymphoma Myeloma Leuk Date: 2011-02

7. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.

Authors: Xuan Zhao; Thomas Sternsdorf; Timothy A Bolger; Ronald M Evans; Tso-Pang Yao
Journal: Mol Cell Biol Date: 2005-10 Impact factor: 4.272

8. Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation.

Authors: Kosaku Okuda; Akihiro Ito; Takashi Uehara
Journal: Biol Pharm Bull Date: 2015 Impact factor: 2.233

9. HDAC4 promotes growth of colon cancer cells via repression of p21.

Authors: Andrew J Wilson; Do-Sun Byun; Shannon Nasser; Lucas B Murray; Kanyalakshmi Ayyanar; Diego Arango; Maria Figueroa; Ari Melnick; Gary D Kao; Leonard H Augenlicht; John M Mariadason
Journal: Mol Biol Cell Date: 2008-07-16 Impact factor: 4.138

10. Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database.

Authors: George A Khoury; Richard C Baliban; Christodoulos A Floudas
Journal: Sci Rep Date: 2011-09-13 Impact factor: 4.379

15 in total

Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.

Review 1. Regulatory signal transduction pathways for class IIa histone deacetylases.

2. Injury-induced HDAC5 nuclear export is essential for axon regeneration.

Review 3. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond.

Review 4. Oncolytic viruses and their application to cancer immunotherapy.

5. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

6. Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.

7. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.

8. Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation.

9. HDAC4 promotes growth of colon cancer cells via repression of p21.

10. Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database.

1. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.

2. Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.

3. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.

4. Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes.

Review 5. Bone Density and Dental External Apical Root Resorption.

6. Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.

Review 7. Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6.

8. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.

9. Chelatable trace zinc causes low, irreproducible KDAC8 activity.

10. Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6.