N Salavati1, U Sovio2, R Plitman Mayo3, D S Charnock-Jones4, G C S Smith5. 1. Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK; Department of Obstetrics and Gynaecology, University Medical Centre of Groningen, University of Groningen, The Netherlands. Electronic address: n.salavati@umcg.nl. 2. Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK. Electronic address: us253@medschl.cam.ac.uk. 3. Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; Department of Engineering, University of Cambridge, Cambridge, UK. Electronic address: rp485@cam.ac.uk. 4. Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Electronic address: dscj1@cam.ac.uk. 5. Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Electronic address: gcss2@cam.ac.uk.
Abstract
INTRODUCTION: Ultrasonic fetal biometry and arterial Doppler flow velocimetry are widely used to assess the risk of pregnancy complications. There is an extensive literature on the relationship between pregnancy outcomes and the size and shape of the placenta. However, ultrasonic fetal biometry and arterial Doppler flow velocimetry have not previously been studied in relation to postnatal placental morphometry in detail. METHODS: We conducted a prospective cohort study of nulliparous women in The Rosie Hospital, Cambridge (UK). We studied a group of 2120 women who had complete data on uterine and umbilical Doppler velocimetry and fetal biometry at 20, 28 and 36 weeks' gestational age, digital images of the placenta available, and delivered a liveborn infant at term. Associations were expressed as the difference in the standard deviation (SD) score of the gestational age adjusted ultrasound measurement (z-score) comparing the lowest and highest decile of the given placental morphometric measurement. RESULTS: The lowest decile of placental surface area was associated with 0.87 SD higher uterine artery Doppler mean pulsatility index (PI) at 20 weeks (95% CI: 0.68 to 1.07, P < 0.001). The lowest decile of placental weight was associated with 0.73 SD higher umbilical artery Doppler PI at 36 weeks (95% CI: 0.54 to 0.93, P < 0.001). The lowest decile of both placental weight and placental area were associated with reduced growth velocity of the fetal abdominal circumference between 20 and 36 weeks (both P < 0.001). CONCLUSION: Placental area and weight are associated with uterine and umbilical blood flow, respectively, and both are associated with fetal growth rate.
INTRODUCTION: Ultrasonic fetal biometry and arterial Doppler flow velocimetry are widely used to assess the risk of pregnancy complications. There is an extensive literature on the relationship between pregnancy outcomes and the size and shape of the placenta. However, ultrasonic fetal biometry and arterial Doppler flow velocimetry have not previously been studied in relation to postnatal placental morphometry in detail. METHODS: We conducted a prospective cohort study of nulliparous women in The Rosie Hospital, Cambridge (UK). We studied a group of 2120 women who had complete data on uterine and umbilical Doppler velocimetry and fetal biometry at 20, 28 and 36 weeks' gestational age, digital images of the placenta available, and delivered a liveborn infant at term. Associations were expressed as the difference in the standard deviation (SD) score of the gestational age adjusted ultrasound measurement (z-score) comparing the lowest and highest decile of the given placental morphometric measurement. RESULTS: The lowest decile of placental surface area was associated with 0.87 SD higher uterine artery Doppler mean pulsatility index (PI) at 20 weeks (95% CI: 0.68 to 1.07, P < 0.001). The lowest decile of placental weight was associated with 0.73 SD higher umbilical artery Doppler PI at 36 weeks (95% CI: 0.54 to 0.93, P < 0.001). The lowest decile of both placental weight and placental area were associated with reduced growth velocity of the fetal abdominal circumference between 20 and 36 weeks (both P < 0.001). CONCLUSION: Placental area and weight are associated with uterine and umbilical blood flow, respectively, and both are associated with fetal growth rate.
Authors: Carolyn M Salafia; Ruchit G Shah; Dawn P Misra; Jennifer K Straughen; Drucilla J Roberts; Larry Troxler; Simon P Morgan; Barbara Eucker; John M Thorp Journal: Placenta Date: 2017-08-30 Impact factor: 3.481
Authors: Helena Lucia Barroso Dos Reis; Neide Aparecida Tosato Boldrini; Ana Fernanda Ribeiro Rangel; Vinicius Felipe Barros; Paulo Roberto Merçon de Vargas; Angélica Espinosa Miranda Journal: PLoS One Date: 2020-04-30 Impact factor: 3.240
Authors: Gad Hatem; Line Hjort; Olof Asplund; Daniel T R Minja; Omari Abdul Msemo; Sofie Lykke Møller; Thomas Lavstsen; Louise Groth-Grunnet; John P A Lusingu; Ola Hansson; Dirk Lund Christensen; Allan A Vaag; Isabella Artner; Thor Theander; Leif Groop; Christentze Schmiegelow; Ib Christian Bygbjerg; Rashmi B Prasad Journal: J Clin Endocrinol Metab Date: 2022-04-19 Impact factor: 6.134
Authors: Nicole Meyer; Anne Schumacher; Urs Coenen; Katja Woidacki; Hannah Schmidt; Jonathan A Lindquist; Peter R Mertens; Ana C Zenclussen Journal: Cells Date: 2020-08-22 Impact factor: 6.600