Literature DB >> 26906286

Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication.

T L Harris1, C J Wenthur1, A Diego-Taboada2, G Mackenzie2, T S Corbitt3, K D Janda1.   

Abstract

3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

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Year:  2016        PMID： 26906286      PMCID： PMC7544009          DOI： 10.1039/c6cc00615a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  27 in total

Review 1.  The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison.

Authors:  Bert Willis; Lisa M Eubanks; Tobin J Dickerson; Kim D Janda
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 2.  The life history of a botulinum toxin molecule.

Authors:  Lance Simpson
Journal:  Toxicon       Date:  2013-03-18       Impact factor: 3.033

3.  Measurement of gastrointestinal pH profiles in normal ambulant human subjects.

Authors:  D F Evans; G Pye; R Bramley; A G Clark; T J Dyson; J D Hardcastle
Journal:  Gut       Date:  1988-08       Impact factor: 23.059

4.  Protein free microcapsules obtained from plant spores as a model for drug delivery: ibuprofen encapsulation, release and taste masking.

Authors:  Alberto Diego-Taboada; Laurent Maillet; Joseph H Banoub; Mark Lorch; Alan S Rigby; Andrew N Boa; Stephen L Atkin; Grahame Mackenzie
Journal:  J Mater Chem B       Date:  2012-11-27       Impact factor: 6.331

5.  A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.

Authors:  L L Simpson
Journal:  Infect Immun       Date:  1986-06       Impact factor: 3.441

6.  Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.

Authors:  M Adler; B Capacio; S S Deshpande
Journal:  Toxicon       Date:  2000-10       Impact factor: 3.033

7.  Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules.

Authors:  Ammar Wakil; Grahame Mackenzie; Alberto Diego-Taboada; J Gordon Bell; Stephen L Atkin
Journal:  Lipids       Date:  2010-05-22       Impact factor: 1.880

8.  Antagonism of botulinum toxin-induced muscle weakness by 3,4-diaminopyridine in rat phrenic nerve-hemidiaphragm preparations.

Authors:  M Adler; J Scovill; G Parker; F J Lebeda; J Piotrowski; S S Deshpande
Journal:  Toxicon       Date:  1995-04       Impact factor: 3.033

9.  Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.

Authors:  G Schiavo; C C Shone; O Rossetto; F C Alexander; C Montecucco
Journal:  J Biol Chem       Date:  1993-06-05       Impact factor: 5.157

10.  Hollow pollen shells to enhance drug delivery.

Authors:  Alberto Diego-Taboada; Stephen T Beckett; Stephen L Atkin; Grahame Mackenzie
Journal:  Pharmaceutics       Date:  2014-03-14       Impact factor: 6.321
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  7 in total

1.  Symptomatic treatment of botulism with a clinically approved small molecule.

Authors:  Edwin Vazquez-Cintron; James Machamer; Celinia Ondeck; Kathleen Pagarigan; Brittany Winner; Paige Bodner; Kyle Kelly; M Ross Pennington; Patrick McNutt
Journal:  JCI Insight       Date:  2020-01-30

2.  Pollen grains as a novel microcarrier for oral delivery of proteins.

Authors:  Shantanu V Lale; Harvinder Singh Gill
Journal:  Int J Pharm       Date:  2018-10-09       Impact factor: 5.875

3.  Species-Specific Biodegradation of Sporopollenin-Based Microcapsules.

Authors:  Teng-Fei Fan; Michael G Potroz; Ee-Lin Tan; Mohammed Shahrudin Ibrahim; Eijiro Miyako; Nam-Joon Cho
Journal:  Sci Rep       Date:  2019-07-03       Impact factor: 4.379

4.  Chemodivergent synthesis of N-(pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines from α-bromoketones and 2-aminopyridines.

Authors:  Yanpeng Liu; Lixue Lu; Haipin Zhou; Feijie Xu; Cong Ma; Zhangjian Huang; Jinyi Xu; Shengtao Xu
Journal:  RSC Adv       Date:  2019-10-28       Impact factor: 4.036

5.  Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems.

Authors:  Siavash Iravani; Rajender S Varma
Journal:  Nanomicro Lett       Date:  2021-05-15

6.  Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A.

Authors:  Phillip H Beske; Katie M Hoffman; James B Machamer; Margaret R Eisen; Patrick M McNutt
Journal:  Sci Rep       Date:  2017-11-20       Impact factor: 4.379

7.  A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A.

Authors:  Christopher S Bailey; Joseph S Zarins-Tutt; Matthias Agbo; Hong Gao; Alberto Diego-Taboada; Maoluo Gan; Refaat B Hamed; Emily R Abraham; Grahame Mackenzie; P Andrew Evans; Rebecca J M Goss
Journal:  Chem Sci       Date:  2019-05-21       Impact factor: 9.825
  7 in total

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