| Literature DB >> 26902764 |
Sylvain Goutelle1, Sandrine Roux2, Marie-Claude Gagnieu3, Florent Valour2, Sébastien Lustig4, Florence Ader5, Frédéric Laurent6, Christian Chidiac5, Tristan Ferry5.
Abstract
The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.Entities:
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Year: 2016 PMID: 26902764 PMCID: PMC4862545 DOI: 10.1128/AAC.02597-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191