| Literature DB >> 26901756 |
Long Wan1, Jian Jiao, Yu Cui, Jingwen Guo, Ning Han, Donghua Di, Di Chang, Pu Wang, Tongying Jiang, Siling Wang.
Abstract
In this paper, hyaluronic acid (HA) functionalized uniform mesoporous carbon spheres (UMCS) were synthesized for targeted enzyme responsive drug delivery using a facile electrostatic attraction strategy. This HA modification ensured stable drug encapsulation in mesoporous carbon nanoparticles in an extracellular environment while increasing colloidal stability, biocompatibility, cell-targeting ability, and controlled cargo release. The cellular uptake experiments of fluorescently labeled mesoporous carbon nanoparticles, with or without HA functionalization, demonstrated that HA-UMCS are able to specifically target cancer cells overexpressing CD44 receptors. Moreover, the cargo loaded doxorubicin (DOX) and verapamil (VER) exhibited a dual pH and hyaluronidase-1 responsive release in the tumor microenvironment. In addition, VER/DOX/HA-UMCS exhibited a superior therapeutic effect on an in vivo HCT-116 tumor in BALB/c nude mice. In summary, it is expected that HA-UMCS will offer a new method for targeted co-delivery of drugs to tumors overexpressing CD44 receptors.Entities:
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Year: 2016 PMID： 26901756 DOI： 10.1088/0957-4484/27/13/135102
Source DB: PubMed Journal: Nanotechnology ISSN： 0957-4484 Impact factor: 3.874