| Literature DB >> 26901067 |
Hikmat A Al-Ahmadie1, Gopa Iyer2,3, Byron H Lee4, Sasinya N Scott1, Rohit Mehra5, Aditya Bagrodia4, Emmet J Jordan3, Sizhi Paul Gao6, Ricardo Ramirez6,7, Eugene K Cha4, Neil B Desai8, Emily C Zabor9, Irina Ostrovnaya9, Anuradha Gopalan1, Ying-Bei Chen1, Samson W Fine1, Satish K Tickoo1, Anupama Gandhi1, Joseph Hreiki10, Agnès Viale10, Maria E Arcila1,10, Guido Dalbagni2,4, Jonathan E Rosenberg2,3, Bernard H Bochner2,4, Dean F Bajorin2,3, Michael F Berger1,10, Victor E Reuter1,2, Barry S Taylor6,9,10, David B Solit2,3,6,10.
Abstract
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.Entities:
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Year: 2016 PMID： 26901067 PMCID： PMC4827439 DOI： 10.1038/ng.3503
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330