Literature DB >> 26900903

Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies.

Patricia I Mathias1, Clayton B'hymer1.   

Abstract

This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research.

Entities:  

Keywords:  Internal exposure; liquid chromatography; mass spectrometry; mercapturic acid; toxicant metabolism; urinary biomarker

Mesh：

Substances：

Year:  2016        PMID： 26900903      PMCID： PMC4894522          DOI： 10.3109/1354750X.2016.1141988

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  122 in total

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Journal:  Nicotine Tob Res       Date:  2008-12       Impact factor: 4.244

2.  Biological monitoring for mutagenic effects of occupational exposure to butadiene.

Authors:  J B Ward; M M Ammenheuser; E B Whorton; W E Bechtold; K T Kelsey; M S Legator
Journal:  Toxicology       Date:  1996-10-28       Impact factor: 4.221

3.  Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations.

Authors:  B K Matuszewski; M L Constanzer; C M Chavez-Eng
Journal:  Anal Chem       Date:  1998-03-01       Impact factor: 6.986

4.  Bromism from excessive cola consumption.

Authors:  B Z Horowitz
Journal:  J Toxicol Clin Toxicol       Date:  1997

5.  Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisons.

Authors:  Pamela M Vacek; Richard J Albertini; Radim J Sram; Patricia Upton; James A Swenberg
Journal:  Chem Biol Interact       Date:  2010-07-07       Impact factor: 5.192

6.  Determination of methyl-, 2-hydroxyethyl- and 2-cyanoethylmercapturic acids as biomarkers of exposure to alkylating agents in cigarette smoke.

Authors:  Gerhard Scherer; Michael Urban; Heinz-Werner Hagedorn; Richard Serafin; Shixia Feng; Sunil Kapur; Raheema Muhammad; Yan Jin; Mohamadi Sarkar; Hans-Juergen Roethig
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2010-02-24       Impact factor: 3.205

7.  Comparison and evaluation of urinary biomarkers for occupational exposure to spray adhesives containing 1-bromopropane.

Authors:  Patricia I Mathias; Kenneth L Cheever; Kevin W Hanley; Katherine L Marlow; Belinda C Johnson; Clayton B'hymer
Journal:  Toxicol Mech Methods       Date:  2012-05-29       Impact factor: 2.987

8.  Biomarkers in Czech workers exposed to 1,3-butadiene: a transitional epidemiologic study.

Authors:  Richard J Albertini; Radim J Srám; Pamela M Vacek; Jeremiah Lynch; Janice A Nicklas; Nico J van Sittert; Peter J Boogaard; Rogene F Henderson; James A Swenberg; Ad D Tates; Jonathan B Ward; Michael Wright; Marinel M Ammenheuser; Blanka Binkova; Walter Blackwell; Franz A de Zwart; Dean Krako; Jennifer Krone; Hendricus Megens; Petra Musilová; Gabriela Rajská; Asoka Ranasinghe; Judah I Rosenblatt; Pavel Rössner; Jiri Rubes; Linda Sullivan; Patricia Upton; Ailko H Zwinderman
Journal:  Res Rep Health Eff Inst       Date:  2003-06

9.  Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice.

Authors:  Gary Carlson
Journal:  J Toxicol Environ Health A       Date:  2004-06-25

10.  Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers.

Authors:  Paola Manini; Luca Buzio; Roberta Andreoli; Matteo Goldoni; Enrico Bergamaschi; Marek Jakubowski; Pavel Vodicka; Ari Hirvonen; Antonio Mutti
Journal:  Toxicol Appl Pharmacol       Date:  2003-06-15       Impact factor: 4.219
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  2 in total

1.  Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog.

Authors:  Marie Roser; David Béal; Camille Eldin; Leslie Gudimard; Fanny Caffin; Fanny Gros-Désormeaux; Daniel Léonço; François Fenaille; Christophe Junot; Christophe Piérard; Thierry Douki
Journal:  Anal Bioanal Chem       Date:  2021-01-07       Impact factor: 4.142

2.  Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers.

Authors:  Menglan Chen; Steven G Carmella; Yupeng Li; Yingchun Zhao; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2020-01-30       Impact factor: 3.739
  2 in total

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