Merav Leiba1,2, Adi Leiba2,3, Lital Keinan-Boker4,5, Abraham Avigdor1,2, Estela Derazne2,3, Hagai Levine6,7, Jeremy D Kark6. 1. Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Ramat Gan, Israel. 2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Surgeon General Headquarters, Medical Corps, Israel Defense Forces, Haifa, Israel. 4. Israel National Cancer Registry, Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel. 5. School of Public Health, University of Haifa, Haifa, Israel. 6. Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel. 7. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Abstract
BACKGROUND: The age-adjusted annual incidence of non-Hodgkin lymphoma (NHL) has risen worldwide. This trend may be affected by the secular increase in height and the sharp upswing in adolescent overweight; these drive increased insulinlike growth factor 1 and chronic inflammation, which may play an etiologic role. This study examined the association of the body mass index (BMI) and height of adolescents with NHL subtypes, which have been insufficiently evaluated. METHODS: Health-related data on 2,352,988 Israeli adolescents, aged 16 to 19 years, who were examined between 1967 and 2011 were linked to the Israel National Cancer Registry to derive the NHL incidence up to December 31, 2012 (4021 cases). Cox proportional hazards modeling was used to estimate the multivariate-adjusted hazard ratio (HR) for NHL subtypes associated with the BMI and height of adolescents. RESULTS: Adolescent overweight and obesity were associated with an HR of 1.25 (95% confidence interval [CI], 1.13-1.37; P = 1.14 × 10(-5) ) for NHL in comparison with normal weight. There was a graded association of height with NHL (P = 4.29 × 10(-9) ), with the tallest adolescents (≥ 95th percentile vs 25th to < 50th percentiles [US Centers for Disease Control and Prevention]) exhibiting an HR of 1.28 (95% CI, 1.04-1.56). Marginal zone lymphoma, primary cutaneous lymphoma (PCL), and diffuse large B-cell lymphoma (DLBCL) showed the strongest associations for overweight/obesity, and DLBCL and PCL showed the strongest associations for height. CONCLUSIONS: The findings of this large cohort study add to the growing body of evidence showing that higher body weight and taller stature during adolescence are associated with an increased risk of NHL and may modestly contribute to its increasing incidence. Further studies are needed to elucidate the mechanisms linking anthropometric measures and NHL risk.
BACKGROUND: The age-adjusted annual incidence of non-Hodgkin lymphoma (NHL) has risen worldwide. This trend may be affected by the secular increase in height and the sharp upswing in adolescent overweight; these drive increased insulinlike growth factor 1 and chronic inflammation, which may play an etiologic role. This study examined the association of the body mass index (BMI) and height of adolescents with NHL subtypes, which have been insufficiently evaluated. METHODS: Health-related data on 2,352,988 Israeli adolescents, aged 16 to 19 years, who were examined between 1967 and 2011 were linked to the Israel National Cancer Registry to derive the NHL incidence up to December 31, 2012 (4021 cases). Cox proportional hazards modeling was used to estimate the multivariate-adjusted hazard ratio (HR) for NHL subtypes associated with the BMI and height of adolescents. RESULTS: Adolescent overweight and obesity were associated with an HR of 1.25 (95% confidence interval [CI], 1.13-1.37; P = 1.14 × 10(-5) ) for NHL in comparison with normal weight. There was a graded association of height with NHL (P = 4.29 × 10(-9) ), with the tallest adolescents (≥ 95th percentile vs 25th to < 50th percentiles [US Centers for Disease Control and Prevention]) exhibiting an HR of 1.28 (95% CI, 1.04-1.56). Marginal zone lymphoma, primary cutaneous lymphoma (PCL), and diffuse large B-cell lymphoma (DLBCL) showed the strongest associations for overweight/obesity, and DLBCL and PCL showed the strongest associations for height. CONCLUSIONS: The findings of this large cohort study add to the growing body of evidence showing that higher body weight and taller stature during adolescence are associated with an increased risk of NHL and may modestly contribute to its increasing incidence. Further studies are needed to elucidate the mechanisms linking anthropometric measures and NHL risk.
Authors: G Twig; N Geva; H Levine; E Derazne; N Goldberger; Z Haklai; A Leiba; J D Kark Journal: Int J Obes (Lond) Date: 2017-10-30 Impact factor: 5.095
Authors: Amy Moore; Eleanor Kane; Zhaoming Wang; Orestis A Panagiotou; Lauren R Teras; Alain Monnereau; Nicole Wong Doo; Mitchell J Machiela; Christine F Skibola; Susan L Slager; Gilles Salles; Nicola J Camp; Paige M Bracci; Alexandra Nieters; Roel C H Vermeulen; Joseph Vijai; Karin E Smedby; Yawei Zhang; Claire M Vajdic; Wendy Cozen; John J Spinelli; Henrik Hjalgrim; Graham G Giles; Brian K Link; Jacqueline Clavel; Alan A Arslan; Mark P Purdue; Lesley F Tinker; Demetrius Albanes; Giovanni M Ferri; Thomas M Habermann; Hans-Olov Adami; Nikolaus Becker; Yolanda Benavente; Simonetta Bisanzi; Paolo Boffetta; Paul Brennan; Angela R Brooks-Wilson; Federico Canzian; Lucia Conde; David G Cox; Karen Curtin; Lenka Foretova; Susan M Gapstur; Hervé Ghesquières; Martha Glenn; Bengt Glimelius; Rebecca D Jackson; Qing Lan; Mark Liebow; Marc Maynadie; James McKay; Mads Melbye; Lucia Miligi; Roger L Milne; Thierry J Molina; Lindsay M Morton; Kari E North; Kenneth Offit; Marina Padoan; Alpa V Patel; Sara Piro; Vignesh Ravichandran; Elio Riboli; Silvia de Sanjose; Richard K Severson; Melissa C Southey; Anthony Staines; Carolyn Stewart; Ruth C Travis; Elisabete Weiderpass; Stephanie Weinstein; Tongzhang Zheng; Stephen J Chanock; Nilanjan Chatterjee; Nathaniel Rothman; Brenda M Birmann; James R Cerhan; Sonja I Berndt Journal: Front Oncol Date: 2020-01-28 Impact factor: 6.244