Adi Horesh1,2, Avishai M Tsur1,2,3,4, Aya Bardugo1,2, Gilad Twig5,6,7,8. 1. The Israel Defense Forces Medical Corps, Ramat Gan, Israel. 2. Department of Military Medicine, Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel. 3. Department of Medicine 'B', Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel. 4. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 5. The Israel Defense Forces Medical Corps, Ramat Gan, Israel. Gilad.Twig@gmail.com. 6. Department of Military Medicine, Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel. Gilad.Twig@gmail.com. 7. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Gilad.Twig@gmail.com. 8. Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel. Gilad.Twig@gmail.com.
Abstract
PURPOSE OF REVIEW: Rates of childhood obesity have been soaring in recent decades. The association between obesity in adulthood and excess morbidity and mortality has been readily established, whereas the association of childhood and adolescent obesity has not. The purpose of this review is to summarize existing data regarding the association of the presence of obesity in childhood/adolescence and early-onset adverse outcomes in adulthood, with specific focus on young adults under the age of 45 years. RECENT FINDINGS: Diabetes, cancer, and cardiometabolic outcomes in midlife are closely linked to childhood and adolescent obesity. Childhood and adolescent obesity confer major risks of excess and premature morbidity and mortality, which may be evident before age 30 years in both sexes. The scientific literature is mixed regarding the independent risk of illness, which may be attributed to childhood BMI regardless of adult BMI, and additional data is required to establish causality between the two. Nonetheless, the increasing prevalence of childhood and adolescent obesity may impose an increase of disease burden in midlife, emphasizing the need for effective interventions to be implemented at a young age.
PURPOSE OF REVIEW: Rates of childhood obesity have been soaring in recent decades. The association between obesity in adulthood and excess morbidity and mortality has been readily established, whereas the association of childhood and adolescent obesity has not. The purpose of this review is to summarize existing data regarding the association of the presence of obesity in childhood/adolescence and early-onset adverse outcomes in adulthood, with specific focus on young adults under the age of 45 years. RECENT FINDINGS:Diabetes, cancer, and cardiometabolic outcomes in midlife are closely linked to childhood and adolescent obesity. Childhood and adolescent obesity confer major risks of excess and premature morbidity and mortality, which may be evident before age 30 years in both sexes. The scientific literature is mixed regarding the independent risk of illness, which may be attributed to childhood BMI regardless of adult BMI, and additional data is required to establish causality between the two. Nonetheless, the increasing prevalence of childhood and adolescent obesity may impose an increase of disease burden in midlife, emphasizing the need for effective interventions to be implemented at a young age.
Entities:
Keywords:
Adolescence; Cancer; Cardiovascular; Type 2 diabetes; Young adults
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