Literature DB >> 26900275

Liver Transplantation in India: At the Crossroads.

Sanjay Nagral1, Aditya Nanavati2, Aabha Nagral3.   

Abstract

As the liver transplant journey in India reaches substantial numbers and suggests quality technical expertise, it is time to dispassionately look at the big picture, identify problems, and consider corrective measures for the future. Several features characterize the current scenario. Although the proportion of deceased donor liver transplants is increasing, besides major regional imbalances, the activity is heavily loaded in favor of the private sector and live donor transplants. The high costs of the procedure, the poor participation of public hospitals, the lack of a national registry, and outcomes reporting are issues of concern. Organ sharing protocols currently based on chronology or institutional rotation need to move to a more justiciable severity-based system. Several measures can expand the deceased donor pool. The safety of the living donor continues to need close scrutiny and focus. Multiple medical challenges unique to the Indian situation are also being thrown up. Although many of the deficits demand state intervention and policy changes the transplant community needs to take notice and highlight them. The future of liver transplantation in India should move toward a more accountable, equitable, and accessible form. We owe this to our citizens who have shown tremendous faith in us by volunteering to be living donors as well as consenting for deceased donation.

Entities:  

Keywords:  ALF, acute liver failure; CMV, cytomegalovirus; CT, computerized tomography; DBD, donation after brain death; DCD, donation after cardiac death; DDLT, deceased donor liver transplant; DNA, deoxyribonucleic acid; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HOTA, Human Organs Transplant Act; ICU, intensive care unit; INASL, Indian Association for Study of the Liver; ISOT, Indian Society of Organ Transplantation; India; KCH, King's College Hospital; LDLT, live donor liver transplantation; LT, liver transplantation; MELD, model for end stage liver disease; NASH, non-alcoholic steatohepatitis; NGO, non-governmental organizations; NOTTO, National Organ and Tissue Transplant Organization; NTORC, non transplant organ retrieval center; OPTN, Organ Procurement Transplant Network; RGJAY, Rajiv Gandhi JeevandayeeArogyaYojana; ROTTO, Regional Organ and Tissue Transplant Organization; SOTTO, State Organ and Tissue Transplant Organization; SRTR, Scientific Registry of Transplant Recipients; TB, tuberculosis; UCSF, University of California San Francisco; UK, United Kingdom; UKELD, United Kingdom End stage Liver Disease; UKNHSBT, UK the National Health Services Blood and Transplant Authority; UNOS, United Network for Organ Sharing; USA, United States of America; ZTCC, Zonal Transplant Coordination Centre; donation after brain death; liver transplantation; living donor liver transplant

Year:  2015        PMID: 26900275      PMCID: PMC4723645          DOI: 10.1016/j.jceh.2015.11.001

Source DB:  PubMed          Journal:  J Clin Exp Hepatol        ISSN: 0973-6883


  47 in total

Review 1.  Changing pattern of donor selection criteria in deceased donor liver transplant: a review of literature.

Authors:  Dronacharya Routh; Sudeep Naidu; Sanjay Sharma; Priya Ranjan; Rajesh Godara
Journal:  J Clin Exp Hepatol       Date:  2013-12-05

Review 2.  Development of the allocation system for deceased donor liver transplantation.

Authors:  John M Coombes; James F Trotter
Journal:  Clin Med Res       Date:  2005-05

3.  Cost and efficacy of immunosuppression using generic products following living donor liver transplantation in India.

Authors:  S Sudhindran; Shameena Aboobacker; Ramachanndran N Menon; G Unnikrishnan; O V Sudheer; Puneet Dhar
Journal:  Indian J Gastroenterol       Date:  2011-12-23

Review 4.  Antituberculous drug-induced liver injury: current perspective.

Authors:  Harshad Devarbhavi
Journal:  Trop Gastroenterol       Date:  2011 Jul-Sep

5.  The growing burden of cancer in India: epidemiology and social context.

Authors:  Mohandas K Mallath; David G Taylor; Rajendra A Badwe; Goura K Rath; V Shanta; C S Pramesh; Raghunadharao Digumarti; Paul Sebastian; Bibhuti B Borthakur; Ashok Kalwar; Sanjay Kapoor; Shaleen Kumar; Jennifer L Gill; Moni A Kuriakose; Hemant Malhotra; Suresh C Sharma; Shilin Shukla; Lokesh Viswanath; Raju T Chacko; Jeremy L Pautu; Kenipakapatnam S Reddy; Kailash S Sharma; Arnie D Purushotham; Richard Sullivan
Journal:  Lancet Oncol       Date:  2014-04-11       Impact factor: 41.316

6.  Excellent outcome of living donor liver transplantation in patients with hepatopulmonary syndrome: a single centre experience.

Authors:  Sanjiv Saigal; Narendra Choudhary; Neeraj Saraf; Hardik Kotecha; Rahul Kakodkar; Ravi Mohanka; Amit Rastogi; Palat Menon; Sanjay Goja; Deepak Govil; Vijay Vohra; Arvinder Soin
Journal:  Clin Transplant       Date:  2013-05-31       Impact factor: 2.863

7.  Liver transplantation without isoniazid prophylaxis for recipients with a history of tuberculosis.

Authors:  Shunji Nagai; Yasuhiro Fujimoto; Kaoru Taira; Hiroto Egawa; Yasutsusgu Takada; Tetsuya Kiuchi; Koichi Tanaka
Journal:  Clin Transplant       Date:  2007 Mar-Apr       Impact factor: 2.863

Review 8.  The evolution in the prioritization for liver transplantation.

Authors:  Evangelos Cholongitas; Andrew K Burroughs
Journal:  Ann Gastroenterol       Date:  2012

Review 9.  Nutrition assessment in patients undergoing liver transplant.

Authors:  Neha Bakshi; Kalyani Singh
Journal:  Indian J Crit Care Med       Date:  2014-10

10.  Preoperative CT evaluation of potential donors in living donor liver transplantation.

Authors:  Sandeep Vohra; Neerav Goyal; Subash Gupta
Journal:  Indian J Radiol Imaging       Date:  2014-10
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  6 in total

1.  Quality of life of liver donors following donor hepatectomy.

Authors:  Biju Chandran; Viju Kumar Bharathan; Johns Shaji Mathew; Binoj Sivasankara Pillai Thankamony Amma; Unnikrishnan Gopalakrishnan; Dinesh Balakrishnan; Ramachandran Narayana Menon; Puneet Dhar; Sudheer Othiyil Vayoth; Sudhindran Surendran
Journal:  Indian J Gastroenterol       Date:  2017-04-10

2.  Heart transplantation in India-are we there yet?

Authors:  Komarakshi Balakrishnan
Journal:  Indian J Thorac Cardiovasc Surg       Date:  2020-07-20

3.  Live donor liver transplantation for alcoholic hepatitis.

Authors:  Ashwani K Singal; Patrick S Kamath
Journal:  Hepatol Int       Date:  2016-10-06       Impact factor: 6.047

Review 4.  The challenges of ascites management: An Indian perspective.

Authors:  Anand V Kulkarni; Madhumita Premkumar; Duvvur Nageshwar Reddy; Padaki Nagaraja Rao
Journal:  Clin Liver Dis (Hoboken)       Date:  2022-07-01

5.  Cost-effectiveness and budgetary impact of HCV treatment with direct-acting antivirals in India including the risk of reinfection.

Authors:  Antoine Chaillon; Sanjay R Mehta; Martin Hoenigl; Sunil S Solomon; Peter Vickerman; Matthew Hickman; Britt Skaathun; Natasha K Martin
Journal:  PLoS One       Date:  2019-06-06       Impact factor: 3.240

6.  Outcomes for high-risk hepatoblastoma in a resource-challenged setting.

Authors:  A Rammohan; M Rela; G V Kumar; J X Scott; N Shanmugam; M S Reddy; P Ramachandran
Journal:  BJS Open       Date:  2020-05-07
  6 in total

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