Raj Kumar Badam1, Jyotsna Suram2, Dara Balaji Gandhi Babu3, Shefali Waghray4, Rahul Marshal1, Sharath Chandra Bontha5, Reddy Lavanya4, Sudheer Kanth6. 1. Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India . 2. Senior Lecturer, Department of Oral Medicine & Radiology, Shadan Dental College , Hyderabad, India . 3. Professor and Head of Department, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India . 4. Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India . 5. Professor, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India . 6. Reader, Department of Oral & Maxillofacial Pathology, Mamatha Dental College , Khammam, Telangana State, India .
Abstract
INTRODUCTION: Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/total thyroidectomy. High-dose Iodine(131) therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine(131) Therapy (RIT). AIM: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy. MATERIALS AND METHODS: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT. STATISTICAL ANALYSIS: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test. RESULTS: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study. CONCLUSION: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related.
INTRODUCTION:Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/total thyroidectomy. High-dose Iodine(131) therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine(131) Therapy (RIT). AIM: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy. MATERIALS AND METHODS: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT. STATISTICAL ANALYSIS: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test. RESULTS: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study. CONCLUSION: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related.
Authors: Carlos D Venencia; Alejandro G Germanier; Silvia R Bustos; Andrea A Giovannini; Eduardo P Wyse Journal: J Nucl Med Date: 2002-01 Impact factor: 10.057