Yasuhiro Maruoka1, Shingo Baba2, Takuro Isoda1, Yoshiyuki Kitamura1, Koichiro Abe3, Masayuki Sasaki4, Hiroshi Honda5. 1. Assistant Professor, Department of Clinical Radiology, Kyushu University Fukuoka, Fukuoka, Japan. 2. Senior Lecturer, Department of Clinical Radiology, Kyushu University Fukuoka, Fukuoka, Japan. 3. Professor, Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. 4. Professor, Department of Health Sciences, Kyushu University Fukuoka, Fukuoka, Japan. 5. Professor, Department of Clinical Radiology, Kyushu University Fukuoka, Fukuoka, Japan.
Abstract
INTRODUCTION: Radioiodine therapy with 131I (131I therapy) after total or near-total thyroidectomy has been established as an effective treatment for Differentiated Thyroid Carcinoma (DTC), but can induce dry mouth symptoms by salivary gland damage and impair the patients' quality of life. AIM: To propose a functional scoring system based on Salivary Gland Scintigraphy (SGS) findings that evaluates development of salivary gland dysfunction secondary to 131I therapy in patients with DTC. MATERIALS AND METHODS: This retrospective study evaluated the records of 279 DTC patients who underwent SGS after one or more round(s) of 131I therapy, using 370 MBqof 99mTc-pertechnetate. The SGS results were assessed using a novel functional scoring system in the Parotid Glands (PGs) and Submandibular Glands (SMGs) according to visual evaluations based on a three-point uptake score, Washout Rate (%WR) score after lemon-juice stimulation, and functional score. The scores were compared among pre treatment, low-dose (<10 GBq), and high-dose (>10 GBq) groups and among pre treatment, symptom-positive, and symptom-negative groups. Risk factors for dry mouth were analyzed by univariate and multivariate logistic regression analyses. RESULTS: Dry mouth symptoms developed in 15.4% of the DTC patients after 131I therapy. The three-point uptake, %WR, and functional scores in both the PG and SMG were statistically significant between low-dose and high-dose groups, and between symptom-positive and symptom-negative groups. The PG/SMG functional scores were independent risk factors for dry mouth (odds ratio, 0.03 and 0.0007 respectively). CONCLUSION: SGS-based PG and SMG functional scores were effective biomarkers to objectively evaluate salivary gland dysfunction, with the high strength of association with dry mouth symptoms.
INTRODUCTION:Radioiodine therapy with 131I (131I therapy) after total or near-total thyroidectomy has been established as an effective treatment for Differentiated Thyroid Carcinoma (DTC), but can induce dry mouth symptoms by salivary gland damage and impair the patients' quality of life. AIM: To propose a functional scoring system based on Salivary Gland Scintigraphy (SGS) findings that evaluates development of salivary gland dysfunction secondary to 131I therapy in patients with DTC. MATERIALS AND METHODS: This retrospective study evaluated the records of 279 DTCpatients who underwent SGS after one or more round(s) of 131I therapy, using 370 MBqof 99mTc-pertechnetate. The SGS results were assessed using a novel functional scoring system in the Parotid Glands (PGs) and Submandibular Glands (SMGs) according to visual evaluations based on a three-point uptake score, Washout Rate (%WR) score after lemon-juice stimulation, and functional score. The scores were compared among pre treatment, low-dose (<10 GBq), and high-dose (>10 GBq) groups and among pre treatment, symptom-positive, and symptom-negative groups. Risk factors for dry mouth were analyzed by univariate and multivariate logistic regression analyses. RESULTS:Dry mouth symptoms developed in 15.4% of the DTCpatients after 131I therapy. The three-point uptake, %WR, and functional scores in both the PG and SMG were statistically significant between low-dose and high-dose groups, and between symptom-positive and symptom-negative groups. The PG/SMG functional scores were independent risk factors for dry mouth (odds ratio, 0.03 and 0.0007 respectively). CONCLUSION:SGS-based PG and SMG functional scores were effective biomarkers to objectively evaluate salivary gland dysfunction, with the high strength of association with dry mouth symptoms.
Entities:
Keywords:
Dry mouth; Nuclear medicine imaging; Radioiodine treatment
Authors: K H Bohuslavizki; W Brenner; S Lassmann; S Tinnemeyer; G Tönshoff; C Sippel; H Wolf; M Clausen; E Henze Journal: Nucl Med Commun Date: 1996-08 Impact factor: 1.690