Literature DB >> 26894145

A Case Report of Metronidazole Induced Neurotoxicity in Liver Abscess Patient and the Usefulness of MRI for its Diagnosis.

Shruti Chandak1, Arjit Agarwal2, Arvind Shukla3, Pawan Joon4.   

Abstract

Metronidazole is a very widely used drug for the treatment of multiple ailments caused by anaerobic bacteria as well as some protozoan parasites. Though its usual side effects are not very serious, yet sometimes it may cause profound adverse effects like neurotoxicity. We present here a case of liver abscess. The patient was treated for a long time with metronidazole and developed sudden onset neurotoxicity which was diagnosed by MRI. The present case also highlights the need of vigilant monitoring of patients on metronidazole for symptoms of neurotoxicity and the usefulness of MRI for diagnosis of the same.

Entities:  

Keywords:  Dentate nucleus; Liver abscess; MRI brain; Metronidazole toxicity

Year:  2016        PMID: 26894145      PMCID: PMC4740673          DOI: 10.7860/JCDR/2016/14900.7031

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  11 in total

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Authors:  J E Krige; I J Beckingham
Journal:  BMJ       Date:  2001-03-03

2.  MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings.

Authors:  E Kim; D G Na; E Y Kim; J H Kim; K R Son; K H Chang
Journal:  AJNR Am J Neuroradiol       Date:  2007-09-20       Impact factor: 3.825

3.  Clinical, neuroimaging and pathological features of 5-nitroimidazole-induced encephalo-neuropathy in two patients: Insights into possible pathogenesis.

Authors:  J Chacko; K Pramod; S Sinha; J Saini; A Mahadevan; R D Bharath; P S Bindu; T C Yasha; A B Taly
Journal:  Neurol India       Date:  2011 Sep-Oct       Impact factor: 2.117

4.  Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy.

Authors:  A Ahmed; D J Loes; E L Bressler
Journal:  Neurology       Date:  1995-03       Impact factor: 9.910

5.  Evaluation of metronidazole toxicity: a prospective study.

Authors:  K Kapoor; M Chandra; D Nag; J K Paliwal; R C Gupta; R C Saxena
Journal:  Int J Clin Pharmacol Res       Date:  1999

6.  Metronidazole-induced encephalopathy: an uncommon scenario.

Authors:  Subrata Chakrabarti; Koushik Pan
Journal:  N Z Med J       Date:  2014-05-02

7.  Case report: MRI of the brain in metronidazole toxicity.

Authors:  Vishal Kalia; Kavita Saggar
Journal:  Indian J Radiol Imaging       Date:  2010-08

8.  Metronidazole-induced neurotoxicity developed in liver cirrhosis.

Authors:  Takatsugu Yamamoto; Koichiro Abe; Hajime Anjiki; Taro Ishii; Yasushi Kuyama
Journal:  J Clin Med Res       Date:  2012-07-20

9.  Metronidazole-induced encephalopathy in a patient with infectious colitis: a case report.

Authors:  Hoon Kim; Young Woo Kim; Seoung Rim Kim; Ik Seong Park; Kwang Wook Jo
Journal:  J Med Case Rep       Date:  2011-02-14

10.  Clinical and imaging perspective and unanswered questions in a case of metronidazole induced encephalopathy.

Authors:  Asif Iqbal; Kamlakar Tripathi; Madhukar Rai; Amit Nandan Dhar Dwivedi
Journal:  Ann Indian Acad Neurol       Date:  2013-10       Impact factor: 1.383

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  3 in total

1.  Metronidazole-induced encephalopathy: a systematic review.

Authors:  Caspar Godthaab Sørensen; William Kristian Karlsson; Faisal Mohammad Amin; Mette Lindelof
Journal:  J Neurol       Date:  2018-12-07       Impact factor: 4.849

2.  Garbled speech: a rare presentation of metronidazole-induced neurotoxicity.

Authors:  Muhammad Arslan Cheema; Fnu Salman; Waqas Ullah; Muhammad Abdullah Zain
Journal:  BMJ Case Rep       Date:  2019-03-01

3.  MRI findings of metronidazole neurotoxicity in a pediatric patient with chronic diarrhea.

Authors:  Rana M Yazdani; Samar Kayfan; Joseph Cao; Rebekah L Clarke; Cory M Pfeifer
Journal:  Radiol Case Rep       Date:  2018-10-22
  3 in total

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