Joshua R Lupton1, Kamil F Faridi1, Seth S Martin1, Sristi Sharma2, Krishnaji Kulkarni3, Steven R Jones1, Erin D Michos4. 1. Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. 2. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 3. Department of Research and Development, Atherotech Diagnostics Laboratory, Birmingham, AL, USA. 4. Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. Electronic address: edonnell@jhmi.edu.
Abstract
BACKGROUND: Cross-sectional studies have found an association between deficiencies in serum vitamin D, as measured by 25-hydroxyvitamin D (25[OH]D), and an atherogenic lipid profile. These studies have focused on a limited panel of lipid values including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). OBJECTIVE: Our study examines the relationship between serum 25(OH)D and an extended lipid panel (Vertical Auto Profile) while controlling for age, gender, glycemic status, and kidney function. METHODS: We used the Very Large Database of Lipids, which includes US adults clinically referred for analysis of their lipid profile from 2009 to 2011. Our study focused on 20,360 subjects who had data for lipids, 25(OH)D, age, gender, hemoglobin A1c, insulin, creatinine, and blood urea nitrogen. Subjects were split into groups based on serum 25(OH)D: deficient (<20 ng/mL), intermediate (≥ 20-30 ng/mL), and optimal (≥ 30 ng/mL). The deficient group was compared to the optimal group using multivariable linear regression. RESULTS: In multivariable-adjusted linear regression, deficient serum 25(OH)D was associated with significantly lower serum HDL-C (-5.1%) and higher total cholesterol (+9.4%), non-HDL-C (+15.4%), directly measured LDL-C (+13.5%), intermediate-density lipoprotein cholesterol (+23.7%), very low-density lipoprotein cholesterol (+19.0%), remnant lipoprotein cholesterol (+18.4%), and TG (+26.4%) when compared with the optimal group. CONCLUSION: Deficient serum 25(OH)D is associated with significantly lower HDL-C and higher directly measured LDL-C, intermediate-density lipoprotein cholesterol, very low-density lipoproteins cholesterol, remnant lipoprotein cholesterol, and TG. Future trials examining vitamin D supplementation and cardiovascular disease risk should consider using changes in an extended lipid panel as an additional outcome measurement.
BACKGROUND: Cross-sectional studies have found an association between deficiencies in serum vitamin D, as measured by 25-hydroxyvitamin D (25[OH]D), and an atherogenic lipid profile. These studies have focused on a limited panel of lipid values including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). OBJECTIVE: Our study examines the relationship between serum 25(OH)D and an extended lipid panel (Vertical Auto Profile) while controlling for age, gender, glycemic status, and kidney function. METHODS: We used the Very Large Database of Lipids, which includes US adults clinically referred for analysis of their lipid profile from 2009 to 2011. Our study focused on 20,360 subjects who had data for lipids, 25(OH)D, age, gender, hemoglobin A1c, insulin, creatinine, and blood ureanitrogen. Subjects were split into groups based on serum 25(OH)D: deficient (<20 ng/mL), intermediate (≥ 20-30 ng/mL), and optimal (≥ 30 ng/mL). The deficient group was compared to the optimal group using multivariable linear regression. RESULTS: In multivariable-adjusted linear regression, deficient serum 25(OH)D was associated with significantly lower serum HDL-C (-5.1%) and higher total cholesterol (+9.4%), non-HDL-C (+15.4%), directly measured LDL-C (+13.5%), intermediate-density lipoprotein cholesterol (+23.7%), very low-density lipoprotein cholesterol (+19.0%), remnant lipoprotein cholesterol (+18.4%), and TG (+26.4%) when compared with the optimal group. CONCLUSION: Deficient serum 25(OH)D is associated with significantly lower HDL-C and higher directly measured LDL-C, intermediate-density lipoprotein cholesterol, very low-density lipoproteins cholesterol, remnant lipoprotein cholesterol, and TG. Future trials examining vitamin D supplementation and cardiovascular disease risk should consider using changes in an extended lipid panel as an additional outcome measurement.
Authors: James L Vacek; Subba Reddy Vanga; Mathew Good; Sue Min Lai; Dhanunjaya Lakkireddy; Patricia A Howard Journal: Am J Cardiol Date: 2011-11-08 Impact factor: 2.778
Authors: Kamil F Faridi; Di Zhao; Seth S Martin; Joshua R Lupton; Steven R Jones; Eliseo Guallar; Christie M Ballantyne; Pamela L Lutsey; Erin D Michos Journal: Nutrition Date: 2017-02-03 Impact factor: 4.008
Authors: Helmuth Haslacher; Sonja Nistler; Delgerdalai Batmyagmar; Elisabeth Ponocny-Seliger; Thomas Perkmann; Thomas M Scherzer; Michael Kundi; Georg Endler; Franz Ratzinger; Alexander Pilger; Oswald F Wagner; Robert Winker Journal: PLoS One Date: 2016-06-15 Impact factor: 3.240
Authors: Charles J Glueck; Vybhav Jetty; Matan Rothschild; Gregory Duhon; Parth Shah; Marloe Prince; Kevin Lee; Michael Goldenberg; Ashwin Kumar; Naila Goldenberg; Ping Wang Journal: N Am J Med Sci Date: 2016-07