Ji Hyun Lee1, Farid Badar1, John Matyas2, Xianggui Qu3, Yang Xia4. 1. Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, 48309, USA. 2. Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. 3. Department of Mathematics and Statistics, Oakland University, Rochester, MI, 48309, USA. 4. Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, 48309, USA. xia@oakland.edu.
Abstract
OBJECTIVE: Our aim was to determine topographical variations in zonal properties of articular cartilage over the medial tibia in an experimental osteoarthritis (OA) model using 7-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: An anterior cruciate ligament (ACL)-transection canine model was subjected to study at 8 (six) and 12 (seven) weeks after the surgery. Each medial tibia was divided into five topographical locations. For each specimen, T2 relaxation (at 0° and 55°) was quantified at microscopic resolution. The imaging data grouped the five locations into two topographical areas (meniscus-covered and -uncovered). RESULTS: The T2 (55°) bulk values from the meniscus-covered area were significantly lower than those from the uncovered area. The total cartilage thicknesses on the meniscus-covered area were significantly thinner than those on the meniscus-uncovered area. Significant differences in the T2 (0°) values were observed in most thicknesses of the four subtissue zones and whole-tissue from the uncovered area, while the same significant changes were detected in the superficial zone from the meniscus-covered area. CONCLUSION: By quantifying high-resolution imaging data both topographically and depth-dependently (zonal-wise), this study demonstrates that the rate of disease progression varies topographically over the medial tibia. Future correlation with OA pathology could lead to better detection of early OA.
OBJECTIVE: Our aim was to determine topographical variations in zonal properties of articular cartilage over the medial tibia in an experimental osteoarthritis (OA) model using 7-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: An anterior cruciate ligament (ACL)-transection canine model was subjected to study at 8 (six) and 12 (seven) weeks after the surgery. Each medial tibia was divided into five topographical locations. For each specimen, T2 relaxation (at 0° and 55°) was quantified at microscopic resolution. The imaging data grouped the five locations into two topographical areas (meniscus-covered and -uncovered). RESULTS: The T2 (55°) bulk values from the meniscus-covered area were significantly lower than those from the uncovered area. The total cartilage thicknesses on the meniscus-covered area were significantly thinner than those on the meniscus-uncovered area. Significant differences in the T2 (0°) values were observed in most thicknesses of the four subtissue zones and whole-tissue from the uncovered area, while the same significant changes were detected in the superficial zone from the meniscus-covered area. CONCLUSION: By quantifying high-resolution imaging data both topographically and depth-dependently (zonal-wise), this study demonstrates that the rate of disease progression varies topographically over the medial tibia. Future correlation with OA pathology could lead to better detection of early OA.
Authors: Siegfried Trattnig; Stefan Zbýň; Benjamin Schmitt; Klaus Friedrich; Vladimir Juras; Pavol Szomolanyi; Wolfgang Bogner Journal: Eur Radiol Date: 2012-06-12 Impact factor: 5.315
Authors: E Fragonas; V Mlynárik; V Jellús; F Micali; A Piras; R Toffanin; R Rizzo; F Vittur Journal: Osteoarthritis Cartilage Date: 1998-01 Impact factor: 6.576
Authors: Louise Murphy; Todd A Schwartz; Charles G Helmick; Jordan B Renner; Gail Tudor; Gary Koch; Anca Dragomir; William D Kalsbeek; Gheorghe Luta; Joanne M Jordan Journal: Arthritis Rheum Date: 2008-09-15