Esra Akyüz Özkan1, Hashem E Khosroshahi2, Halil İbrahim Serin3, Zeynep Tuba Özdemir4, Mahmut Kılıç5, Meral Ekim6, U Aliye Geçit1, Esra Domur1. 1. Department of Pediatrics, Medical Faculty, Bozok University Yozgat, Turkey. 2. Department of Pediatric Cardiology, Medical Faculty, Bozok University Yozgat, Turkey. 3. Department of Radiology, Medical Faculty, Bozok University Yozgat, Turkey. 4. Department of Internal Medicine, Medical Faculty, Bozok University Yozgat, Turkey. 5. Department of Public Health, Medical Faculty, Bozok University Yozgat, Turkey. 6. Department of Biochemistry, Medical Faculty, Bozok University Yozgat, Turkey.
Abstract
BACKGROUND: Obesity is associated with many risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension and leads to early atherosclerosis. The aim of this study was to investigate the relation of the mean platelet volume (MPV) and the carotid intima media thickness (CIMT) on cardiac functions among obese children. MATERIALS AND METHODS: Sixty obese children, with body mass index percentile were >95% and forty eight healthy controls were enrolled in the study. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid function tests, hemoglobin, white blood cell, MPV and insulin resistance were evaluated. CIMT was measured by using high-resolution ultrasound and echocardiography was performed to all individuals. RESULTS: MPV and CIMT values were found significantly higher in obese children than controls. There was positive correlation between CIMT and age, body surface area (BSA), systolic and diastolic blood pressure, left ventricular meridional end-systolic wall stress (ESWSm), myocardial fiber stress (MFS), stroke volume (SV) and insulin and negative correlation with left ventricle end-systolic elastance by single beat technique (Ees(sb)) and arterial elastance (Ea). There was no correlation between LVM, cardiac risk profiles and CIMT. Multiple stepwise regression analyses revealed that ESWSm (β=0.337, P=0.049) was only independent factor on CIMT. MPV values showed negative correlation with ALT, AST, Free T4, thyroid stimulating hormone and positive correlation with age and BSA. CONCLUSION: Current study showed that obesity has an independent impact on CIMT and MPV values in children. Increased CIMT in obese children leads significant increase in ESWSm and decrease in Ea and Ees(sb).
BACKGROUND:Obesity is associated with many risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension and leads to early atherosclerosis. The aim of this study was to investigate the relation of the mean platelet volume (MPV) and the carotid intima media thickness (CIMT) on cardiac functions among obesechildren. MATERIALS AND METHODS: Sixty obesechildren, with body mass index percentile were >95% and forty eight healthy controls were enrolled in the study. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid function tests, hemoglobin, white blood cell, MPV and insulin resistance were evaluated. CIMT was measured by using high-resolution ultrasound and echocardiography was performed to all individuals. RESULTS: MPV and CIMT values were found significantly higher in obesechildren than controls. There was positive correlation between CIMT and age, body surface area (BSA), systolic and diastolic blood pressure, left ventricular meridional end-systolic wall stress (ESWSm), myocardial fiber stress (MFS), stroke volume (SV) and insulin and negative correlation with left ventricle end-systolic elastance by single beat technique (Ees(sb)) and arterial elastance (Ea). There was no correlation between LVM, cardiac risk profiles and CIMT. Multiple stepwise regression analyses revealed that ESWSm (β=0.337, P=0.049) was only independent factor on CIMT. MPV values showed negative correlation with ALT, AST, Free T4, thyroid stimulating hormone and positive correlation with age and BSA. CONCLUSION: Current study showed that obesity has an independent impact on CIMT and MPV values in children. Increased CIMT in obesechildren leads significant increase in ESWSm and decrease in Ea and Ees(sb).
Authors: Navtej S Chahal; Tiong K Lim; Piyush Jain; John C Chambers; Jaspal S Kooner; Roxy Senior Journal: J Am Soc Echocardiogr Date: 2010-12 Impact factor: 5.251
Authors: G de Simone; R B Devereux; M J Roman; A Ganau; P S Saba; M H Alderman; J H Laragh Journal: J Am Coll Cardiol Date: 1994-05 Impact factor: 24.094
Authors: Lucia Pacifico; Vito Cantisani; Paolo Ricci; John F Osborn; Elisa Schiavo; Caterina Anania; Eva Ferrara; Giuliano Dvisic; Claudio Chiesa Journal: Pediatr Res Date: 2008-04 Impact factor: 3.756