Literature DB >> 26885234

Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk.

Shengjun Zhou1, Jikuang Zhao1, Zhepei Wang1, Keqin Li1, Sheng Nie1, Feng Gao1, Jie Sun1, Xiang Gao1, Yi Huang1.   

Abstract

We aimed to evaluate the association of rs964184 of BUD13-ZNF259 gene with the risk of hemorrhagic stroke (HS). A total of 138 HS cases and 587 controls were recruited for the association of rs964184 of BUD13-ZNF259 gene with the risk of HS. Tm shift PCR was used for genotyping. We were unable to find the association of rs964184 of BUD13-ZNF259 gene with the risk of HS (P>0.05). Significant difference was found in the TG level among the three genotypes (CC: 1.51±1.02; CG: 1.68±1.10; GG: 1.90±1.11, P=0.036). The TG level showed strong correlation with rs964184 genotypes (P=0.010, correlation=0.101). Significantly higher TC, HDL-C, and LDL-C levels were observed in the case group. And no difference was found in the TG, ApoA-I, ApoB. Our case-control study supported the significant association between rs964184 genotype and the blood TG concentration, although we were unable to find association between BUD13-ZNF259 rs964184 and the risk of HS in Han Chinese.

Entities:  

Keywords:  BUD13-ZNF259; Hemorrhagic stroke; SNP; TG; rs964184

Year:  2015        PMID： 26885234      PMCID： PMC4730020     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


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