Literature DB >> 26884865

Anacardic acid sensitizes prostate cancer cells to radiation therapy by regulating H2AX expression.

Kun Yao1, Xianzhen Jiang1, Leye He1, Yuxin Tang1, Guangming Yin1, Qing Zeng1, Zhiqiang Jiang1, Jing Tan1.   

Abstract

Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygiumadstringens, has been reported as potential antitumor agents in various cancers including prostate cancer (PC). However, the effects and mechanism of AA on the radiosensitivity of prostate cancer remains unknown. The results indicated that AA exhibited strong antitumor activity in PC cell lines, either as a single agentor in combination with radiation. AA significantly induced the downregulation of H2AX and p-H2AX expression, increase of cell apoptosis and decreasing of cell invasion, which were reversed by overexpressed H2AX. These results suggest that AA sensitize prostate cancer cells to radiation therapy by repressing H2AX expression.

Entities:  

Keywords:  Anacardic acid; H2AX; prostate cancer; radio therapy

Mesh：

Substances：

Year:  2015        PMID： 26884865      PMCID： PMC4730078     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  24 in total

1.  Uncoupling effect of anacardic acids from cashew nut shell oil on oxidative phosphorylation of rat liver mitochondria.

Authors:  M Toyomizu; K Okamoto; T Ishibashi; Z Chen; T Nakatsu
Journal:  Life Sci       Date:  2000       Impact factor: 5.037

2.  Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Authors:  Steven L Sanders; Ahmad R Arida; Funita P Phan
Journal:  Mol Cell Biol       Date:  2010-08-02       Impact factor: 4.272

3.  PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells.

Authors:  Nupur N Gangopadhyay; James D Luketich; Amy Opest; Rodney Landreneau; Matthew J Schuchert
Journal:  Cancer Invest       Date:  2014-06-04       Impact factor: 2.176

4.  Induction of the endoplasmic reticulum stress and autophagy in human lung carcinoma A549 cells by anacardic acid.

Authors:  Yeong-Ae Seong; Pyung-Gyun Shin; Jin-Soo Yoon; Anandam Kasin Yadunandam; Gun-Do Kim
Journal:  Cell Biochem Biophys       Date:  2014-03       Impact factor: 2.194

5.  Effect of 6-nonadecyl salicylic acid and its methyl ester on the induction of micronuclei in polychromatic erythrocytes in mouse peripheral blood.

Authors:  Hortensia Rosas Acevedo; Maritere Domínguez Rojas; Sandra Díaz Barriga Arceo; Marcos Soto Hernández; Mariano Martínez Vázquez; Teresa Terrazas; Gustavo Valencia del Toro
Journal:  Mutat Res       Date:  2006-07-20       Impact factor: 2.433

6.  Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.

Authors:  Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Brendan D Price
Journal:  FEBS Lett       Date:  2006-07-10       Impact factor: 4.124

7.  Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.

Authors:  Bokyung Sung; Manoj K Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Journal:  Blood       Date:  2008-03-18       Impact factor: 22.113

Review 8.  H2AX: functional roles and potential applications.

Authors:  Jennifer S Dickey; Christophe E Redon; Asako J Nakamura; Brandon J Baird; Olga A Sedelnikova; William M Bonner
Journal:  Chromosoma       Date:  2009-08-26       Impact factor: 4.316

9.  Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling.

Authors:  Jing Tan; Binghai Chen; Leye He; Yuxin Tang; Zhiqiang Jiang; Guangmin Yin; Jinrong Wang; Xianzhen Jiang
Journal:  Chin J Cancer Res       Date:  2012-12       Impact factor: 5.087

Review 10.  Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.

Authors:  Andrea Kinner; Wenqi Wu; Christian Staudt; George Iliakis
Journal:  Nucleic Acids Res       Date:  2008-09-04       Impact factor: 16.971
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  5 in total

1.  Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling.

Authors:  Subramanyam Dasari; Angela Lincy Prem Antony Samy; Andre Kajdacsy-Balla; Maarten C Bosland; Gnanasekar Munirathinam
Journal:  Food Chem Toxicol       Date:  2018-02-09       Impact factor: 6.023

2.  Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway.

Authors:  Jing Tan; Xianzhen Jiang; Guangming Yin; Leye He; Jianye Liu; Zhi Long; Zhiqiang Jiang; Kun Yao
Journal:  Oncol Rep       Date:  2017-07-20       Impact factor: 3.906

Review 3.  Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway.

Authors:  Haneen Amawi; Charles R Ashby; Temesgen Samuel; Ramalingam Peraman; Amit K Tiwari
Journal:  Nutrients       Date:  2017-08-21       Impact factor: 5.717

Review 4.  Epigenetic modulators as therapeutic targets in prostate cancer.

Authors:  Inês Graça; Eva Pereira-Silva; Rui Henrique; Graham Packham; Simon J Crabb; Carmen Jerónimo
Journal:  Clin Epigenetics       Date:  2016-09-15       Impact factor: 6.551

5.  Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT.

Authors:  Yifan Liu; Eun Ju Yang; Changxiang Shi; Pui Kei Mou; Baoyuan Zhang; Changjie Wu; Junfang Lyu; Joong Sup Shim
Journal:  Int J Biol Sci       Date:  2020-03-25       Impact factor: 6.580
  5 in total

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