Literature DB >> 19707781

H2AX: functional roles and potential applications.

Jennifer S Dickey1, Christophe E Redon, Asako J Nakamura, Brandon J Baird, Olga A Sedelnikova, William M Bonner.   

Abstract

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed gamma-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of gamma-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

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Year:  2009        PMID： 19707781      PMCID： PMC3094848          DOI： 10.1007/s00412-009-0234-4

Source DB:  PubMed          Journal:  Chromosoma        ISSN： 0009-5915            Impact factor:   4.316


  103 in total

Review 1.  Microscopic imaging of DNA repair foci in irradiated normal tissues.

Authors:  Nirmal Bhogal; Farid Jalali; Robert G Bristow
Journal:  Int J Radiat Biol       Date:  2009-09       Impact factor: 2.694

2.  Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

Authors:  Chengrong Lu; Feng Zhu; Yong-Yeon Cho; Faqing Tang; Tatyana Zykova; Wei-ya Ma; Ann M Bode; Zigang Dong
Journal:  Mol Cell       Date:  2006-07-07       Impact factor: 17.970

3.  Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Authors:  Arkady Celeste; Oscar Fernandez-Capetillo; Michael J Kruhlak; Duane R Pilch; David W Staudt; Alicia Lee; Robert F Bonner; William M Bonner; André Nussenzweig
Journal:  Nat Cell Biol       Date:  2003-07       Impact factor: 28.824

4.  New roads to FA/BRCA pathway: H2AX.

Authors:  Alex Lyakhovich; Jordi Surrallés
Journal:  Cell Cycle       Date:  2007-05-01       Impact factor: 4.534

5.  DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.

Authors:  Michael A Kuefner; Saskia Grudzenski; Siegfried A Schwab; Melanie Wiederseiner; Martina Heckmann; Werner Bautz; Markus Lobrich; Michael Uder
Journal:  Invest Radiol       Date:  2009-08       Impact factor: 6.016

6.  Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide.

Authors:  Peggy L Olive; Judit P Banáth; Laura T Sinnott
Journal:  Cancer Res       Date:  2004-08-01       Impact factor: 12.701

7.  Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines.

Authors:  Judit P Banáth; Susan H Macphail; Peggy L Olive
Journal:  Cancer Res       Date:  2004-10-01       Impact factor: 12.701

8.  Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.

Authors:  Judith E Karp; Karen Flatten; Eric J Feldman; Jacqueline M Greer; David A Loegering; Rebecca M Ricklis; Lawrence E Morris; Ellen Ritchie; B Douglas Smith; Valerie Ironside; Timothy Talbott; Gail Roboz; Son B Le; Xue Wei Meng; Paula A Schneider; Nga T Dai; Alex A Adjei; Steven D Gore; Mark J Levis; John J Wright; Elizabeth Garrett-Mayer; Scott H Kaufmann
Journal:  Blood       Date:  2008-12-24       Impact factor: 22.113

9.  Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma.

Authors:  Karen L Novik; John J Spinelli; Amy C Macarthur; Karey Shumansky; Payal Sipahimalani; Stephen Leach; Agnes Lai; Joseph M Connors; Randy D Gascoyne; Richard P Gallagher; Angela R Brooks-Wilson
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-06       Impact factor: 4.254

10.  WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.

Authors:  Andrew Xiao; Haitao Li; David Shechter; Sung Hee Ahn; Laura A Fabrizio; Hediye Erdjument-Bromage; Satoko Ishibe-Murakami; Bin Wang; Paul Tempst; Kay Hofmann; Dinshaw J Patel; Stephen J Elledge; C David Allis
Journal:  Nature       Date:  2008-12-17       Impact factor: 49.962
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  120 in total

1.  Possible association between genetic variants in the H2AFX promoter region and risk of adult glioma in a Chinese Han population.

Authors:  Weiwei Fan; Keke Zhou; Yingjie Zhao; Wenting Wu; Hongyan Chen; Li Jin; Gong Chen; Jinlong Shi; Qingyi Wei; Tianbao Zhang; Guhong Du; Ying Mao; Daru Lu; Liangfu Zhou
Journal:  J Neurooncol       Date:  2011-04-22       Impact factor: 4.130

2.  DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.

Authors:  Dominik Geisel; Elke Zimmermann; Matthias Rief; Johannes Greupner; Michael Laule; Fabian Knebel; Bernd Hamm; Marc Dewey
Journal:  Eur Radiol       Date:  2012-04-17       Impact factor: 5.315

3.  2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Authors:  Stephen Boulware; Tammy Fields; Elizabeth McIvor; K Leslie Powell; Erika L Abel; Karen M Vasquez; Michael C MacLeod
Journal:  Toxicol Appl Pharmacol       Date:  2012-06-23       Impact factor: 4.219

4.  Functional characterization of a cancer causing mutation in human replication protein A.

Authors:  Cathy S Hass; Lokesh Gakhar; Marc S Wold
Journal:  Mol Cancer Res       Date:  2010-06-29       Impact factor: 5.852

5.  Prevalence of FA-D2 rare complementation group of Fanconi anemia in Serbia.

Authors:  Vujić Dragana; Petrović Sandra; Lazić Emilija; Kuzmanović Miloš; Leskovac Andreja; Joksić Ivana; Mićić Dragan; Jovanović Ankica; Zečević Zeljko; Guć-Šćekić Marija; Cirković Sanja; Joksić Gordana
Journal:  Indian J Pediatr       Date:  2013-12-10       Impact factor: 1.967

6.  A Preliminary Study: Human Fibroid Stro-1+/CD44+ Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1+/CD44+ Cells.

Authors:  Lauren E Prusinski Fernung; Ayman Al-Hendy; Qiwei Yang
Journal:  Reprod Sci       Date:  2018-06-28       Impact factor: 3.060

7.  Whole-blood immunoassay for γH2AX as a radiation biodosimetry assay with minimal sample preparation.

Authors:  Matthew L Johnston; Erik F Young; Kenneth L Shepard
Journal:  Radiat Environ Biophys       Date:  2015-05-03       Impact factor: 1.925

Review 8.  DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

Authors:  Jeff Sekelsky
Journal:  Genetics       Date:  2017-02       Impact factor: 4.562

9.  MS5 Mediates Early Meiotic Progression and Its Natural Variants May Have Applications for Hybrid Production in Brassica napus.

Authors:  Qiang Xin; Yi Shen; Xi Li; Wei Lu; Xiang Wang; Xue Han; Faming Dong; Lili Wan; Guangsheng Yang; Dengfeng Hong; Zhukuan Cheng
Journal:  Plant Cell       Date:  2016-05-18       Impact factor: 11.277

10.  Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.

Authors:  Eugene Izumchenko; John Saydi; Kevin D Brown
Journal:  DNA Repair (Amst)       Date:  2012-10-11
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