Literature DB >> 26884666

Thymectomy Cures Diabetes Mellitus and Ameliorates Myasthenia Gravis in a Patient with Thymus Hyperplasia and Hyperthyroidism: Report of a Case.

Shiyun Feng1, Yao Zhang1, Youbin Cui1, Yu Chen2.   

Abstract

Myasthenia gravis (MG) is a devastating autoimmune disease that involves the acetylcholine receptor (AchR) in the postsynaptic membrane of the neuromuscular junction. It is not uncommon for MG to accompany with other autoimmune diseases and complicate with multiple organ dysfunction. Here, we report on an 18-year-old female patient with a rare case of MG concomitant with thymus hyperplasia, diabetes mellitus, and hyperthyroidism. After full excision of the hyperplastic thymus gland, the patient's muscle weakness was greatly improved and her blood glucose level was restored to normal at the 6-month follow-up.

Entities:  

Keywords:  Diabetes; Hyperthyroidism; Myasthenia gravis; Thymectomy; Thymus hyperplasia

Year:  2015        PMID: 26884666      PMCID: PMC4744207          DOI: 10.1007/s12262-015-1339-z

Source DB:  PubMed          Journal:  Indian J Surg        ISSN: 0973-9793            Impact factor:   0.656


  5 in total

1.  MYASTHENIA GRAVIS AND TUMORS OF THE THYMIC REGION: REPORT OF A CASE IN WHICH THE TUMOR WAS REMOVED.

Authors:  A Blalock; M F Mason; H J Morgan; S S Riven
Journal:  Ann Surg       Date:  1939-10       Impact factor: 12.969

2.  Thymic microenvironmental alterations in experimentally induced diabetes.

Authors:  Patrícia R A Nagib; Jacy Gameiro; Luiz Guilherme Stivanin-Silva; Maria Sueli Parreira de Arruda; Déa Maria Serra Villa-Verde; Wilson Savino; Liana Verinaud
Journal:  Immunobiology       Date:  2010-02-16       Impact factor: 3.144

3.  Projection of an immunological self shadow within the thymus by the aire protein.

Authors:  Mark S Anderson; Emily S Venanzi; Ludger Klein; Zhibin Chen; Stuart P Berzins; Shannon J Turley; Harald von Boehmer; Roderick Bronson; Andrée Dierich; Christophe Benoist; Diane Mathis
Journal:  Science       Date:  2002-10-10       Impact factor: 47.728

4.  Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.

Authors:  A A Like; E Kislauskis; R R Williams; A A Rossini
Journal:  Science       Date:  1982-05-07       Impact factor: 47.728

5.  Antibodies to acetylcholinesterase cross-reacting with thyroglobulin in myasthenia gravis and Graves's disease.

Authors:  D G Mappouras; G Philippou; S Haralambous; S J Tzartos; A Balafas; A Souvatzoglou; P Lymberi
Journal:  Clin Exp Immunol       Date:  1995-05       Impact factor: 4.330

  5 in total

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