Literature DB >> 7041259

Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.

A A Like, E Kislauskis, R R Williams, A A Rossini.   

Abstract

Complete neonatal thymectomy reduced the frequency of spontaneous diabetes mellitus in BioBreeding/Worcester rats from 27 to 3 percent. Incomplete thymectomy also significantly reduced the frequency of diabetes (to 9 percent). These findings strengthen the hypothesis that thymus-dependent, cell-mediated autoimmune destruction of pancreatic B cells is responsible for the pathogenesis of diabetes in this experimental animal.

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Year:  1982        PMID： 7041259     DOI： 10.1126/science.7041259

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  44 in total

Review 1.  Use of nonobese diabetic mice to understand human type 1 diabetes.

Authors:  Terri C Thayer; S Brian Wilson; Clayton E Mathews
Journal:  Endocrinol Metab Clin North Am       Date:  2010-07-08       Impact factor: 4.741

2.  Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors:  E J Weringer; A A Like
Journal:  Am J Pathol       Date:  1986-10       Impact factor: 4.307

3.  Resistance to tolerance induction in the diabetes-prone biobreeding rat as one manifestation of abnormal responses to superantigens.

Authors:  K S Sellins; D P Gold; D Bellgrau
Journal:  Diabetologia       Date:  1996-01       Impact factor: 10.122

4.  Suppression of concanavalin A-induced responses in splenic lymphocytes by activated macrophages in the non-obese diabetic mouse.

Authors:  K Yokono; Y Kawase; M Nagata; N Hatamori; S Baba
Journal:  Diabetologia       Date:  1989-01       Impact factor: 10.122

5.  Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

Authors:  A A Like; V Dirodi; S Thomas; D L Guberski; A A Rossini
Journal:  Am J Pathol       Date:  1984-10       Impact factor: 4.307

6.  Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat.

Authors:  T Dyrberg; P Poussier; F Nakhooda; E B Marliss; A Lernmark
Journal:  Diabetologia       Date:  1984-02       Impact factor: 10.122

7.  Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

Authors:  A A Rossini; D Faustman; B A Woda; A A Like; I Szymanski; J P Mordes
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

8.  WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus.

Authors:  D M See; J G Tilles
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

Review 9.  Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells?

Authors:  E J Rashba; E P Reich; C A Janeway; R S Sherwin
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

10.  Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

Authors:  J Doukas; J P Mordes; C Swymer; D Niedzwiecki; R Mason; J Rozing; A A Rossini; D L Greiner
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307
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