Literature DB >> 26882560

The translational relevance of Drosophila in drug discovery.

Ismael Fernández-Hernández1, Eulalia Scheenaard1, Giulia Pollarolo1, Cayetano Gonzalez2.   

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Year:  2016        PMID: 26882560      PMCID: PMC4818774          DOI: 10.15252/embr.201642080

Source DB:  PubMed          Journal:  EMBO Rep        ISSN: 1469-221X            Impact factor:   8.807


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  10 in total

1.  Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity.

Authors:  Aashiq H Kachroo; Jon M Laurent; Christopher M Yellman; Austin G Meyer; Claus O Wilke; Edward M Marcotte
Journal:  Science       Date:  2015-05-22       Impact factor: 47.728

2.  Comparative genomics of the eukaryotes.

Authors:  G M Rubin; M D Yandell; J R Wortman; G L Gabor Miklos; C R Nelson; I K Hariharan; M E Fortini; P W Li; R Apweiler; W Fleischmann; J M Cherry; S Henikoff; M P Skupski; S Misra; M Ashburner; E Birney; M S Boguski; T Brody; P Brokstein; S E Celniker; S A Chervitz; D Coates; A Cravchik; A Gabrielian; R F Galle; W M Gelbart; R A George; L S Goldstein; F Gong; P Guan; N L Harris; B A Hay; R A Hoskins; J Li; Z Li; R O Hynes; S J Jones; P M Kuehl; B Lemaitre; J T Littleton; D K Morrison; C Mungall; P H O'Farrell; O K Pickeral; C Shue; L B Vosshall; J Zhang; Q Zhao; X H Zheng; S Lewis
Journal:  Science       Date:  2000-03-24       Impact factor: 47.728

3.  Systematic screen of chemotherapeutics in Drosophila stem cell tumors.

Authors:  Michele Markstein; Samantha Dettorre; Julio Cho; Ralph A Neumüller; Sören Craig-Müller; Norbert Perrimon
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-10       Impact factor: 11.205

Review 4.  Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.

Authors:  Udai Bhan Pandey; Charles D Nichols
Journal:  Pharmacol Rev       Date:  2011-03-17       Impact factor: 25.468

5.  Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.

Authors:  Guangxun Gao; Liang Chen; Chuanshu Huang
Journal:  Curr Mol Pharmacol       Date:  2014       Impact factor: 3.339

6.  Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Authors:  Shuang Chang; Steven M Bray; Zigang Li; Daniela C Zarnescu; Chuan He; Peng Jin; Stephen T Warren
Journal:  Nat Chem Biol       Date:  2008-03-09       Impact factor: 15.040

7.  Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.

Authors:  Arvin C Dar; Tirtha K Das; Kevan M Shokat; Ross L Cagan
Journal:  Nature       Date:  2012-06-06       Impact factor: 49.962

8.  An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Authors:  Lee F Willoughby; Tanja Schlosser; Samuel A Manning; John P Parisot; Ian P Street; Helena E Richardson; Patrick O Humbert; Anthony M Brumby
Journal:  Dis Model Mech       Date:  2012-09-20       Impact factor: 5.758

9.  A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer.

Authors:  Mara Gladstone; Barbara Frederick; Di Zheng; Anthony Edwards; Petros Yoon; Stefanie Stickel; Tessie DeLaney; Daniel C Chan; David Raben; Tin Tin Su
Journal:  Dis Model Mech       Date:  2012-02-16       Impact factor: 5.758

10.  The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity.

Authors:  Cathy Slack; Nazif Alic; Andrea Foley; Melissa Cabecinha; Matthew P Hoddinott; Linda Partridge
Journal:  Cell       Date:  2015-06-25       Impact factor: 41.582

  10 in total
  17 in total

1.  Alpha-lipoic acid ameliorates tauopathy-induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor.

Authors:  Elahe Zarini-Gakiye; Nima Sanadgol; Kazem Parivar; Gholamhassan Vaezi
Journal:  Metab Brain Dis       Date:  2021-02-06       Impact factor: 3.584

Review 2.  Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction.

Authors:  Mathieu Bartoletti; Daryl A Bosco; Sandrine Da Cruz; Clotilde Lagier-Tourenne; Nicole Liachko; Sebastian Markmiller; Kristin M Webster; Kristi A Wharton
Journal:  J Neurosci       Date:  2019-10-16       Impact factor: 6.167

3.  Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies.

Authors:  Jonathan Zirin; Yanhui Hu; Luping Liu; Donghui Yang-Zhou; Ryan Colbeth; Dong Yan; Ben Ewen-Campen; Rong Tao; Eric Vogt; Sara VanNest; Cooper Cavers; Christians Villalta; Aram Comjean; Jin Sun; Xia Wang; Yu Jia; Ruibao Zhu; Ping Peng; Jinchao Yu; Da Shen; Yuhao Qiu; Limmond Ayisi; Henna Ragoowansi; Ethan Fenton; Senait Efrem; Annette Parks; Kuniaki Saito; Shu Kondo; Liz Perkins; Stephanie E Mohr; Jianquan Ni; Norbert Perrimon
Journal:  Genetics       Date:  2020-02-18       Impact factor: 4.562

4.  Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system.

Authors:  Kevin Kim; Elizabeth A Lane; Aurelia Saftien; Haiyun Wang; Yue Xu; Frederik Wirtz-Peitz; Norbert Perrimon
Journal:  Proc Natl Acad Sci U S A       Date:  2020-04-28       Impact factor: 11.205

5.  Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster.

Authors:  Daniel A Martinez-Perez; Marlene Jimenez-Del-Rio; Carlos Velez-Pardo
Journal:  Neurotox Res       Date:  2018-04-17       Impact factor: 3.911

Review 6.  Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease.

Authors:  Urmila Maitra; Lukasz Ciesla
Journal:  Medchemcomm       Date:  2019-04-30       Impact factor: 3.597

Review 7.  Drug discovery from natural products - Old problems and novel solutions for the treatment of neurodegenerative diseases.

Authors:  Urmila Maitra; Cayman Stephen; Lukasz M Ciesla
Journal:  J Pharm Biomed Anal       Date:  2021-12-24       Impact factor: 3.935

Review 8.  Drug screening in Drosophila; why, when, and when not?

Authors:  Tin Tin Su
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2019-05-05       Impact factor: 5.814

9.  Mechanosensory neuron regeneration in adult Drosophila.

Authors:  Ismael Fernández-Hernández; Evan B Marsh; Michael A Bonaguidi
Journal:  Development       Date:  2021-03-10       Impact factor: 6.868

Review 10.  Modelling Cooperative Tumorigenesis in Drosophila.

Authors:  Helena E Richardson; Marta Portela
Journal:  Biomed Res Int       Date:  2018-03-06       Impact factor: 3.411

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