| Literature DB >> 26878747 |
Atefeh Shamosi1, Davood Mehrabani2,3, Mahmoud Azami1, Somayeh Ebrahimi-Barough1, Vahid Siavashi4, Hossein Ghanbari5, Esmaeel Sharifi1, Reza Roozafzoon1, Jafar Ai1,6.
Abstract
The capacity of gelatin/chitosan/bioactive glass nanopowders (GEL/CS/BGNPs) scaffolds was investigated for increasing human endometrial stem cells (hEnSCs) differentiation into the endothelial cells in the presence of angiogenic factors. GEL/CS nanofibrous scaffold with different contents of BGNPs were fabricated and assessed. Expression of endothelial markers (CD31, vascular endothelial cadherin (VE-cadherin), and KDR) in differentiated cells was evaluated. Results showed the diameter of nanofiber increases with decreasing the BG content in GEL/CS scaffolds. Moreover, in vitro study indicated that the GEL/CS/BGNPs scaffold with 1.5% BGNPs content provided a suitable three-dimensional structure for endothelial cells differentiation. Thus, the GEL/CS/BGNPs scaffold can be recommended for blood vessels repair.Entities:
Keywords: Endothelial cells; gelatin/chitosan/bioglass; human endometrial stem cells; nanofiber scaffold
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Year: 2016 PMID： 26878747 DOI： 10.3109/21691401.2016.1138493
Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678